6e5d

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'''Unreleased structure'''
 
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The entry 6e5d is ON HOLD until Jul 20 2020
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==Crystal structure of LpqN involved in cell envelope biogenesis of Mycobacterium tuberculosis==
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<StructureSection load='6e5d' size='340' side='right'caption='[[6e5d]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6e5d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E5D FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e5d OCA], [https://pdbe.org/6e5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e5d RCSB], [https://www.ebi.ac.uk/pdbsum/6e5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e5d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LPQN_MYCTU LPQN_MYCTU] Involved in cell envelope biogenesis. May act as a membrane fusion protein, connecting MmpL transporters with periplasmic proteins, and play a role in cell envelope lipid changes during biofilm maturation.<ref>PMID:31471317</ref> Is also a virulence factor required for intracellular survival (PubMed:30118682). Associates with CBL, a host ubiquitin ligase, and probably blocks the normal functions of CBL and disturbs CBL-mediated antibacterial activity (PubMed:30118682). Interaction counteracts antibacterial defense but causes a reciprocal enhancement of antiviral defense (PubMed:30118676, PubMed:30118682).<ref>PMID:30118682</ref> <ref>PMID:30118676</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Rajavel M]]
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[[Category: Su CC]]
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[[Category: Yu EW]]

Current revision

Crystal structure of LpqN involved in cell envelope biogenesis of Mycobacterium tuberculosis

PDB ID 6e5d

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