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2oym

From Proteopedia

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[[Image:2oym.jpg|left|200px]]
 
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{{Structure
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==Endo-glycoceramidase II from Rhodococcus sp.: five-membered iminocyclitol complex==
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|PDB= 2oym |SIZE=350|CAPTION= <scene name='initialview01'>2oym</scene>, resolution 1.860&Aring;
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<StructureSection load='2oym' size='340' side='right'caption='[[2oym]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MNI:N-{[(2R,3R,4R,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)PYRROLIDIN-2-YL]METHYL}-4-(DIMETHYLAMINO)BENZAMIDE'>MNI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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<table><tr><td colspan='2'>[[2oym]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp. Rhodococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OYM FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Endoglycosylceramidase Endoglycosylceramidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.123 3.2.1.123] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MNI:N-{[(2R,3R,4R,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)PYRROLIDIN-2-YL]METHYL}-4-(DIMETHYLAMINO)BENZAMIDE'>MNI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oym OCA], [https://pdbe.org/2oym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oym RCSB], [https://www.ebi.ac.uk/pdbsum/2oym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oym ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oym OCA], [http://www.ebi.ac.uk/pdbsum/2oym PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oym RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/O33853_RHOSO O33853_RHOSO]
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== Evolutionary Conservation ==
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'''Endo-glycoceramidase II from Rhodococcus sp.: five-membered iminocyclitol complex'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oy/2oym_consurf.spt"</scriptWhenChecked>
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2OYM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp. Rhodococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYM OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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The structural basis of glycosidase inhibition by five-membered iminocyclitols: the clan a glycoside hydrolase endoglycoceramidase as a model system., Caines ME, Hancock SM, Tarling CA, Wrodnigg TM, Stick RV, Stutz AE, Vasella A, Withers SG, Strynadka NC, Angew Chem Int Ed Engl. 2007;46(24):4474-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17487923 17487923]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oym ConSurf].
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[[Category: Endoglycosylceramidase]]
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<div style="clear:both"></div>
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[[Category: Rhodococcus sp.]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Caines, M E.C.]]
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[[Category: Large Structures]]
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[[Category: Strynadka, N C.J.]]
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[[Category: Rhodococcus sp]]
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[[Category: (alpha/beta)8 (tim) barrel]]
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[[Category: Caines MEC]]
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[[Category: hydrolase]]
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[[Category: Strynadka NCJ]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:25:17 2008''
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Current revision

Endo-glycoceramidase II from Rhodococcus sp.: five-membered iminocyclitol complex

PDB ID 2oym

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