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| | ==Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus== | | ==Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus== |
| - | <StructureSection load='2nnz' size='340' side='right' caption='[[2nnz]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2nnz' size='340' side='right'caption='[[2nnz]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2nnz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfu Arcfu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NNZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NNZ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2nnz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NNZ FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AF2241 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224325 ARCFU])</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nnz OCA], [https://pdbe.org/2nnz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nnz RCSB], [https://www.ebi.ac.uk/pdbsum/2nnz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nnz ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nnz OCA], [http://pdbe.org/2nnz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nnz RCSB], [http://www.ebi.ac.uk/pdbsum/2nnz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nnz ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/O28042_ARCFU O28042_ARCFU] |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Arcfu]] | + | [[Category: Archaeoglobus fulgidus DSM 4304]] |
| - | [[Category: Ai, X]] | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith, C H]] | + | [[Category: Ai X]] |
| - | [[Category: Choy, W Y]] | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Li, S S.C]] | + | [[Category: Choy WY]] |
| - | [[Category: OCSP, Ontario Centre for Structural Proteomics]] | + | [[Category: Li SSC]] |
| - | [[Category: Semesib, A]] | + | [[Category: Semesib A]] |
| - | [[Category: Yee, A]] | + | [[Category: Yee A]] |
| - | [[Category: Beta-barrel]]
| + | |
| - | [[Category: Ocsp]]
| + | |
| - | [[Category: Ontario centre for structural proteomic]]
| + | |
| - | [[Category: Structural genomic]]
| + | |
| - | [[Category: Unknown function]]
| + | |
| Structural highlights
Function
O28042_ARCFU
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
AF2241 is a hypothetical protein from Archaeoglobus fulgidus and it belongs to the PFam domain of unknown function 369 (DUF369). NMR structural determination reveals that AF2241 adopts a cyclophilin-like fold, with a beta-barrel core composed of eight beta-strands, one alpha-helix, and one 3(10) helix located at each end of the barrel. The protein displays a high structural similarity to TM1367, another member of DUF369 whose structure has been determined recently by X-ray crystallography. Structural similarity search shows that AF2241 also has a high similarity to human cyclophilin A, however, sequence alignment and electrostatic potential analysis reveal that the residues in the PPIase catalytic site of human cyclophilin A are not conserved in AF2241 or TM1367. Instead, a putative active site of AF2241 maps to a negatively charged pocket composed of 9 conserved residues. Our results suggest that although AF2241 adopts the same fold as the human cyclophilin A, it may have distinct biological function.
Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold.,Ai X, Li L, Semesi A, Yee A, Arrowsmith CH, Li SS, Choy WY J Biomol NMR. 2007 Aug;38(4):353-8. Epub 2007 Jul 4. PMID:17610131[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Ai X, Li L, Semesi A, Yee A, Arrowsmith CH, Li SS, Choy WY. Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold. J Biomol NMR. 2007 Aug;38(4):353-8. Epub 2007 Jul 4. PMID:17610131 doi:10.1007/s10858-007-9172-8
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