2p1j

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[[Image:2p1j.gif|left|200px]]
 
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{{Structure
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==Crystal structure of a polC-type DNA polymerase III exonuclease domain from Thermotoga maritima==
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|PDB= 2p1j |SIZE=350|CAPTION= <scene name='initialview01'>2p1j</scene>, resolution 2.500&Aring;
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<StructureSection load='2p1j' size='340' side='right'caption='[[2p1j]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2p1j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P1J FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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|GENE= polC, TM_0576 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p1j OCA], [https://pdbe.org/2p1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p1j RCSB], [https://www.ebi.ac.uk/pdbsum/2p1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p1j ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2p1j TOPSAN]</span></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00479 EXOIII]</span>
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p1j OCA], [http://www.ebi.ac.uk/pdbsum/2p1j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2p1j RCSB]</span>
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[https://www.uniprot.org/uniprot/DPO3_THEMA DPO3_THEMA] Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p1/2p1j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p1j ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of a polC-type DNA polymerase III exonuclease domain from Thermotoga maritima'''
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2P1J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P1J OCA].
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[[Category: Large Structures]]
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Thermotoga maritima MSB8]]
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[[Category: Single protein]]
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[[Category: Almo SC]]
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[[Category: Thermotoga maritima]]
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[[Category: Bain KT]]
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[[Category: Almo, S C.]]
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[[Category: Bonanno JB]]
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[[Category: Bain, K T.]]
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[[Category: Burley SK]]
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[[Category: Bonanno, J B.]]
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[[Category: Izuka M]]
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[[Category: Burley, S K.]]
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[[Category: Rutter M]]
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[[Category: Izuka, M.]]
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[[Category: Sauder JM]]
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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[[Category: Smith D]]
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[[Category: Rutter, M.]]
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[[Category: Sridhar V]]
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[[Category: Sauder, M J.]]
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[[Category: Wasserman S]]
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[[Category: Smith, D.]]
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[[Category: Sridhar, V.]]
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[[Category: Wasserman, S.]]
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[[Category: exonuclease]]
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[[Category: new york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: protein structure initiative]]
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[[Category: psi-2]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:26:57 2008''
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Current revision

Crystal structure of a polC-type DNA polymerase III exonuclease domain from Thermotoga maritima

PDB ID 2p1j

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