2mz4
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
==Solution Structure of mu-SLPTX-Ssm6a== | ==Solution Structure of mu-SLPTX-Ssm6a== | ||
| - | <StructureSection load='2mz4' size='340' side='right' caption='[[2mz4 | + | <StructureSection load='2mz4' size='340' side='right'caption='[[2mz4]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2mz4]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2mz4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Scolopendra_subspinipes Scolopendra subspinipes]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MZ4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mz4 OCA], [https://pdbe.org/2mz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mz4 RCSB], [https://www.ebi.ac.uk/pdbsum/2mz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mz4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TX32A_SCOMU TX32A_SCOMU] Gating-modifier toxin that inhibits voltage-gated sodium channel with a preference for hNav1.7/SCN9A (IC(50)=25.4 nM) over hNav1.1/SCN1A (IC(50)=4.1 uM), hNav1.2/SCN2A (IC(50)=813 nM), and hNav1.6/SCN8A (IC(50)=15.2 uM) (PubMed:24082113). Is an effective analgesic in rodent pain models, since it is several-fold more effective than morphine in a rodent model of formalin-induced pain and is equipotent with morphine in its ability to reduce thermal and acid-induced pain (PubMed:24082113). In addition, this peptide shows a high level of resistance to proteases and a high thermal stability that may be explained by its predominant composition of alpha-helices (PubMed:24082113).<ref>PMID:24082113</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Scolopendra subspinipes]] |
| - | [[Category: Kim | + | [[Category: Kim JH]] |
| - | [[Category: | + | [[Category: Kim JI]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Solution Structure of mu-SLPTX-Ssm6a
| |||||||||||
