2p1z

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[[Image:2p1z.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of phosphoribosyltransferase from Corynebacterium diphtheriae==
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|PDB= 2p1z |SIZE=350|CAPTION= <scene name='initialview01'>2p1z</scene>, resolution 2.44&Aring;
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<StructureSection load='2p1z' size='340' side='right'caption='[[2p1z]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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<table><tr><td colspan='2'>[[2p1z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cordi Cordi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P1Z FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotate_phosphoribosyltransferase Orotate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.10 2.4.2.10] </span>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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|GENE= pyrE, DIP2097 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1717 Corynebacterium diphtheriae])
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pyrE, DIP2097 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=257309 CORDI])</td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK00455 pyrE]</span>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Orotate_phosphoribosyltransferase Orotate phosphoribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.10 2.4.2.10] </span></td></tr>
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|RELATEDENTRY=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p1z OCA], [https://pdbe.org/2p1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p1z RCSB], [https://www.ebi.ac.uk/pdbsum/2p1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p1z ProSAT], [https://www.topsan.org/Proteins/MCSG/2p1z TOPSAN]</span></td></tr>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p1z OCA], [http://www.ebi.ac.uk/pdbsum/2p1z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2p1z RCSB]</span>
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</table>
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}}
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== Function ==
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[[https://www.uniprot.org/uniprot/Q6NF12_CORDI Q6NF12_CORDI]] Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).[HAMAP-Rule:MF_01208][SAAS:SAAS00015698]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p1/2p1z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p1z ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of phosphoribosyltransferase from Corynebacterium diphtheriae'''
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==See Also==
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2P1Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Corynebacterium_diphtheriae Corynebacterium diphtheriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P1Z OCA].
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[[Category: Cordi]]
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[[Category: Large Structures]]
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[[Category: Orotate phosphoribosyltransferase]]
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[[Category: Chang, C]]
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[[Category: Clancy, S]]
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[[Category: Joachimiak, A]]
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[[Category: Li, H]]
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[[Category: Structural genomic]]
[[Category: Corynebacterium diphtheriae]]
[[Category: Corynebacterium diphtheriae]]
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[[Category: Orotate phosphoribosyltransferase]]
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[[Category: Mcsg]]
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[[Category: Single protein]]
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[[Category: Phosphoribosyltransferase]]
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[[Category: Chang, C.]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Clancy, S.]]
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[[Category: Transferase]]
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[[Category: Joachimiak, A.]]
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[[Category: Li, H.]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: corynebacterium diphtheriae]]
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[[Category: mcsg]]
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[[Category: midwest center for structural genomic]]
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[[Category: phosphoribosyltransferase]]
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[[Category: protein structure initiative]]
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[[Category: psi-2]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:27:21 2008''
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Current revision

Crystal structure of phosphoribosyltransferase from Corynebacterium diphtheriae

PDB ID 2p1z

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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