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| | ==Solution structure of Q388A3 PDZ domain== | | ==Solution structure of Q388A3 PDZ domain== |
| - | <StructureSection load='2nb4' size='340' side='right' caption='[[2nb4]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2nb4' size='340' side='right'caption='[[2nb4]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2nb4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tryb2 Tryb2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NB4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2nb4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NB4 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tb10.61.1430 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=185431 TRYB2])</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nb4 OCA], [https://pdbe.org/2nb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nb4 RCSB], [https://www.ebi.ac.uk/pdbsum/2nb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nb4 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nb4 OCA], [http://pdbe.org/2nb4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nb4 RCSB], [http://www.ebi.ac.uk/pdbsum/2nb4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nb4 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q388A3_TRYB2 Q388A3_TRYB2] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Tryb2]] | + | [[Category: Large Structures]] |
| - | [[Category: Mei, S]] | + | [[Category: Trypanosoma brucei brucei TREU927]] |
| - | [[Category: Pdz nmr]] | + | [[Category: Mei S]] |
| - | [[Category: Unknown function]]
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| Structural highlights
Function
Q388A3_TRYB2
Publication Abstract from PubMed
PDZ domains are abundant protein interaction modules that often recognize short amino acid motifs at the C-termini of target proteins and regulate multiple biological processes. So far, no PDZ domain in Trypanosoma brucei, an eukaryotic parasite causing sleeping sickness, has been studied. Q388A3, conserved in the related kinetoplastid parasites, is a 1634-residue protein containing a PDZ domain at its C-terminus. In this work, the solution structure of Q388A3 PDZ domain was solved by NMR spectroscopy. Q388A3 PDZ domain adopts a PDZ-like fold composed by a five-stranded beta-sheet capped by two alpha-helices, which is similar to the PDZ domains from HtrA family proteins. Meanwhile, Q388A3 PDZ domain shows some structural features quite different from HtrA PDZ domain.
Solution structure of Q388A3 PDZ domain from Trypanosoma brucei.,Mei S, Dong Y, Zhang J, Zhang X, Tu X J Struct Biol. 2016 May;194(2):214-7. doi: 10.1016/j.jsb.2016.02.018. Epub 2016, Feb 22. PMID:26917351[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Mei S, Dong Y, Zhang J, Zhang X, Tu X. Solution structure of Q388A3 PDZ domain from Trypanosoma brucei. J Struct Biol. 2016 May;194(2):214-7. doi: 10.1016/j.jsb.2016.02.018. Epub 2016, Feb 22. PMID:26917351 doi:http://dx.doi.org/10.1016/j.jsb.2016.02.018
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