2mto

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:45, 14 June 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Non-reducible analogues of alpha-conotoxin RgIA: [2,8]-cis dicarba RgIA==
==Non-reducible analogues of alpha-conotoxin RgIA: [2,8]-cis dicarba RgIA==
-
<StructureSection load='2mto' size='340' side='right' caption='[[2mto]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='2mto' size='340' side='right'caption='[[2mto]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2mto]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MTO FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2mto]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_regius Conus regius]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MTO FirstGlance]. <br>
-
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jut|2jut]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mto OCA], [https://pdbe.org/2mto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mto RCSB], [https://www.ebi.ac.uk/pdbsum/2mto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mto ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mto OCA], [http://pdbe.org/2mto PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mto RCSB], [http://www.ebi.ac.uk/pdbsum/2mto PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mto ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/CXA1A_CONRE CXA1A_CONRE]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. Is a specific blocker of the alpha-9/alpha-10 nAChR. Is also active on alpha-7 (but 1000-fold less potent) and on alpha-2/beta-2, alpha-2/beta-4, alpha-3/beta-4, alpha-3/beta-2, alpha-4/beta-2, alpha-4/beta-4 and alpha-6 or -3/beta-2 or -3 (but 2000-fold less potent) channels.<ref>PMID:16445293</ref>
+
[https://www.uniprot.org/uniprot/CA1A_CONRE CA1A_CONRE] This toxin target two types of receptors, the nicotinic acetylcholine receptor (nAChR) and the G-protein-coupled receptor GABA(B). It specifically inhibits the alpha-9-alpha-10/CHRNA9-CHRNA10 nAChR, with preference for rat receptors (PubMed:16445293, PubMed:21888386, PubMed:22774872, PubMed:25740413, PubMed:28223528, PubMed:18242183, PubMed:18295795). It interacts with the alpha-10(+)/alpha-9(-)interface of the receptor (PubMed:25740413). It shows a two order of magnitude species difference potency for the rat versus human alpha-9-alpha-10 nAChR, due to the Thr-86 located in the alpha-9 nAChR subunit (PubMed:22774872). This toxin also shows inhibition of high voltage-activated (HVA) calcium channels (Cav2.2) by acting on GABA(B) receptors (GABBR1 and GABBR2) (PubMed:18945902, PubMed:21888386). In vivo, this toxin produces an acute antinociceptive effect in peripheral nerve-injured rats, which may be related to the inhibition of immune cell buildup at the site of nerve injury (PubMed:17101979). In addition, when intramuscularly injected into rats following chronic constriction injury of the sciatic nerve, this toxin protects peripheral nervous tissues as well as prevents central maladaptive plasticity by inhibiting glial cell activation (PubMed:25008370).<ref>PMID:16445293</ref> <ref>PMID:17101979</ref> <ref>PMID:18242183</ref> <ref>PMID:18295795</ref> <ref>PMID:18945902</ref> <ref>PMID:21888386</ref> <ref>PMID:22774872</ref> <ref>PMID:25008370</ref> <ref>PMID:25740413</ref> <ref>PMID:28223528</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 22:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Chhabra, S]]
+
[[Category: Conus regius]]
-
[[Category: Norton, R]]
+
[[Category: Large Structures]]
-
[[Category: Robinson, S]]
+
[[Category: Chhabra S]]
-
[[Category: Dicarba]]
+
[[Category: Norton R]]
-
[[Category: Non-reducible]]
+
[[Category: Robinson S]]
-
[[Category: Rgia]]
+
-
[[Category: Toxin]]
+

Current revision

Non-reducible analogues of alpha-conotoxin RgIA: [2,8]-cis dicarba RgIA

PDB ID 2mto

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2mto"
Personal tools