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2mt5

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==Isolated Ring domain==
==Isolated Ring domain==
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<StructureSection load='2mt5' size='340' side='right' caption='[[2mt5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2mt5' size='340' side='right'caption='[[2mt5]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mt5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MT5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2mt5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MT5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ANAPC11, HSPC214 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mt5 OCA], [http://pdbe.org/2mt5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mt5 RCSB], [http://www.ebi.ac.uk/pdbsum/2mt5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mt5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mt5 OCA], [https://pdbe.org/2mt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mt5 RCSB], [https://www.ebi.ac.uk/pdbsum/2mt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mt5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/APC11_HUMAN APC11_HUMAN]] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.<ref>PMID:11739784</ref> <ref>PMID:18485873</ref>
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[https://www.uniprot.org/uniprot/APC11_HUMAN APC11_HUMAN] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.<ref>PMID:11739784</ref> <ref>PMID:18485873</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Brown, N G]]
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[[Category: Large Structures]]
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[[Category: Frye, J J]]
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[[Category: Brown NG]]
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[[Category: Jarvis, M]]
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[[Category: Frye JJ]]
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[[Category: Peters, J]]
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[[Category: Jarvis M]]
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[[Category: Petzold, G]]
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[[Category: Peters J]]
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[[Category: Qiao, R]]
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[[Category: Petzold G]]
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[[Category: Royappa, G]]
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[[Category: Qiao R]]
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[[Category: Schulman, B]]
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[[Category: Royappa G]]
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[[Category: Stark, H]]
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[[Category: Schulman B]]
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[[Category: Vanderlinden, R]]
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[[Category: Stark H]]
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[[Category: Watson, E R]]
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[[Category: Vanderlinden R]]
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[[Category: Weissman, F]]
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[[Category: Watson ER]]
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[[Category: Metal binding protein]]
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[[Category: Weissman F]]
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[[Category: Ring domain]]
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[[Category: Zinc binding domain]]
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Current revision

Isolated Ring domain

PDB ID 2mt5

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