P73
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='Human p73 DNA-binding domain complex with Tris, glycerol and Zn+2 ion (grey), [[2xwc]]' scene='46/468230/Cv/2' pspeed='8'> |
'''p73''' is a protein related to p53 tumor suppressor. It is involved in cell cycle regulation and induction of apoptosis<ref>PMID:9891077</ref>. p73 has several variants differing in their C- or N-terminal. p73 contains DNA-binding domain (DBD residues 112-312); tetramerization domain (TD residues 351-398). | '''p73''' is a protein related to p53 tumor suppressor. It is involved in cell cycle regulation and induction of apoptosis<ref>PMID:9891077</ref>. p73 has several variants differing in their C- or N-terminal. p73 contains DNA-binding domain (DBD residues 112-312); tetramerization domain (TD residues 351-398). | ||
== Structural highlights == | == Structural highlights == | ||
| - | *<scene name='46/468230/Cv/ | + | *<scene name='46/468230/Cv/5'>1st Zn coordination site</scene>. |
| - | *<scene name='46/468230/Cv/ | + | *<scene name='46/468230/Cv/6'>2nd Zn coordination site</scene>. |
</StructureSection> | </StructureSection> | ||
== 3D Structures of p73 == | == 3D Structures of p73 == | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| + | Domains - DNA-binding (DBD) 112-311; Tetramerization (TD) 351-398; C-terminal 439-506. | ||
[[1cok]] – hp73 C terminal – human – NMR | [[1cok]] – hp73 C terminal – human – NMR | ||
| Line 19: | Line 21: | ||
[[2xwc]] – hp73 DBD (mutant)<br /> | [[2xwc]] – hp73 DBD (mutant)<br /> | ||
[[2nb1]] - hp73 TD (mutant) + hp63 TD (mutant)<br /> | [[2nb1]] - hp73 TD (mutant) + hp63 TD (mutant)<br /> | ||
| - | [[3vd0]], [[3vd1]], [[3vd2]], [[4g82]], [[4g83]], [[4guo]], [[4guq]], [[5kbd]] – hp73 DBD + DNA<br /> | + | [[3vd0]], [[3vd1]], [[3vd2]], [[4g82]], [[4g83]], [[4guo]], [[4guq]], [[5kbd]], [[7ezj]] – hp73 DBD + DNA<br /> |
[[4a63]] – hp73 DBD + apoptosis stimulating of p53 protein<br /> | [[4a63]] – hp73 DBD + apoptosis stimulating of p53 protein<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of p73
Updated on 21-August-2023
Domains - DNA-binding (DBD) 112-311; Tetramerization (TD) 351-398; C-terminal 439-506.
1cok – hp73 C terminal – human – NMR
2kby – hp73 TD – NMR
2wqi, 2wqj, 2wtt - hp73 TD
5hob, 5hoc - hp73 TD (mutant)
2xwc – hp73 DBD (mutant)
2nb1 - hp73 TD (mutant) + hp63 TD (mutant)
3vd0, 3vd1, 3vd2, 4g82, 4g83, 4guo, 4guq, 5kbd, 7ezj – hp73 DBD + DNA
4a63 – hp73 DBD + apoptosis stimulating of p53 protein
References
- ↑ Di Como CJ, Gaiddon C, Prives C. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Mol Cell Biol. 1999 Feb;19(2):1438-49. PMID:9891077
