This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
P73
From Proteopedia
| (2 intermediate revisions not shown.) | |||
| Line 4: | Line 4: | ||
'''p73''' is a protein related to p53 tumor suppressor. It is involved in cell cycle regulation and induction of apoptosis<ref>PMID:9891077</ref>. p73 has several variants differing in their C- or N-terminal. p73 contains DNA-binding domain (DBD residues 112-312); tetramerization domain (TD residues 351-398). | '''p73''' is a protein related to p53 tumor suppressor. It is involved in cell cycle regulation and induction of apoptosis<ref>PMID:9891077</ref>. p73 has several variants differing in their C- or N-terminal. p73 contains DNA-binding domain (DBD residues 112-312); tetramerization domain (TD residues 351-398). | ||
== Structural highlights == | == Structural highlights == | ||
| - | *<scene name='46/468230/Cv/ | + | *<scene name='46/468230/Cv/5'>1st Zn coordination site</scene>. |
| - | *<scene name='46/468230/Cv/ | + | *<scene name='46/468230/Cv/6'>2nd Zn coordination site</scene>. |
</StructureSection> | </StructureSection> | ||
== 3D Structures of p73 == | == 3D Structures of p73 == | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | |||
| + | Domains - DNA-binding (DBD) 112-311; Tetramerization (TD) 351-398; C-terminal 439-506. | ||
[[1cok]] – hp73 C terminal – human – NMR | [[1cok]] – hp73 C terminal – human – NMR | ||
| Line 19: | Line 21: | ||
[[2xwc]] – hp73 DBD (mutant)<br /> | [[2xwc]] – hp73 DBD (mutant)<br /> | ||
[[2nb1]] - hp73 TD (mutant) + hp63 TD (mutant)<br /> | [[2nb1]] - hp73 TD (mutant) + hp63 TD (mutant)<br /> | ||
| - | [[3vd0]], [[3vd1]], [[3vd2]], [[4g82]], [[4g83]], [[4guo]], [[4guq]], [[5kbd]] – hp73 DBD + DNA<br /> | + | [[3vd0]], [[3vd1]], [[3vd2]], [[4g82]], [[4g83]], [[4guo]], [[4guq]], [[5kbd]], [[7ezj]] – hp73 DBD + DNA<br /> |
[[4a63]] – hp73 DBD + apoptosis stimulating of p53 protein<br /> | [[4a63]] – hp73 DBD + apoptosis stimulating of p53 protein<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
3D Structures of p73
Updated on 21-August-2023
Domains - DNA-binding (DBD) 112-311; Tetramerization (TD) 351-398; C-terminal 439-506.
1cok – hp73 C terminal – human – NMR
2kby – hp73 TD – NMR
2wqi, 2wqj, 2wtt - hp73 TD
5hob, 5hoc - hp73 TD (mutant)
2xwc – hp73 DBD (mutant)
2nb1 - hp73 TD (mutant) + hp63 TD (mutant)
3vd0, 3vd1, 3vd2, 4g82, 4g83, 4guo, 4guq, 5kbd, 7ezj – hp73 DBD + DNA
4a63 – hp73 DBD + apoptosis stimulating of p53 protein
References
- ↑ Di Como CJ, Gaiddon C, Prives C. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Mol Cell Biol. 1999 Feb;19(2):1438-49. PMID:9891077
