Parvalbumin

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== Structural highlights ==
== Structural highlights ==
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PVA contains a <scene name='46/466520/Cv/6'>heptacoordinated Ca+2 ion binding to 7 oxygen atoms</scene> in a <scene name='46/466520/Cv/3'>typical EF-hand</scene> coordination<ref>PMID:10548066</ref>. <scene name='46/466520/Cv/8'>Calcium ion is coordinated by seven oxygen atoms that form a pentagonal bipyramid </scene>.
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PVA contains a <scene name='46/466520/Cv/10'>heptacoordinated Ca+2 ion binding to 7 oxygen atoms</scene> in a <scene name='46/466520/Cv/11'>typical EF-hand</scene> coordination<ref>PMID:10548066</ref>. Water molecules are shown as red spheres. <scene name='46/466520/Cv/12'>Calcium ion is coordinated by seven oxygen atoms that form a pentagonal bipyramid </scene>.
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*<scene name='46/466520/Cv/9'>Ammonium ion coordination site</scene>. Water molecules shown as red spheres.
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*<scene name='46/466520/Cv/13'>Ammonium ion coordination site</scene>.
</StructureSection>
</StructureSection>
== 3D Structures of Parvalbumin ==
== 3D Structures of Parvalbumin ==
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*α-parvalbumin
*α-parvalbumin
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**[[5pal]] – PVA-α - shark<br />
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**[[1rjv]], [[1rk9]] - hPVA-α - human – NMR<br />
**[[1rtp]], [[1rwy]] - rPVA-α - rat<br />
**[[1rtp]], [[1rwy]] - rPVA-α - rat<br />
**[[2jww]] - rPVA-α Ca-free – NMR<br />
**[[2jww]] - rPVA-α Ca-free – NMR<br />
**[[1g33]], [[1s3p]], [[1xvj]], [[3f45]] - rPVA-α (mutant)<br />
**[[1g33]], [[1s3p]], [[1xvj]], [[3f45]] - rPVA-α (mutant)<br />
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**[[1rjv]], [[1rk9]] - hPVA-α - human – NMR
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**[[5pal]] – PVA-α - shark<br />
*β-parvalbumin (oncomodulin)
*β-parvalbumin (oncomodulin)
 +
**[[1ttx]] - hPVA-β (mutant) – NMR<br />
**[[2nln]] - rPVA-β Ca-free – NMR<br />
**[[2nln]] - rPVA-β Ca-free – NMR<br />
**[[1rro]], [[1omd]] - rPVA-β <br />
**[[1rro]], [[1omd]] - rPVA-β <br />
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**[[1ttx]] - hPVA-β (mutant) – NMR<br />
 
**[[3fs7]] - chPVA-β - chicken<br />
**[[3fs7]] - chPVA-β - chicken<br />
**[[2kqy]] – chPVA-β – NMR<br />
**[[2kqy]] – chPVA-β – NMR<br />

Current revision

Pike parvalbumin complex with Ca+2 ions (green), ammonium ion (blue), acetyl and formate (PDB entry 2pvb)

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3D Structures of Parvalbumin

Updated on 05-December-2021

References

  1. ↑ Cates MS, Teodoro ML, Phillips GN Jr. Molecular mechanisms of calcium and magnesium binding to parvalbumin. Biophys J. 2002 Mar;82(3):1133-46. PMID:11867433 doi:http://dx.doi.org/10.1016/S0006-3495(02)75472-6
  2. ↑ Fohr UG, Weber BR, Muntener M, Staudenmann W, Hughes GJ, Frutiger S, Banville D, Schafer BW, Heizmann CW. Human alpha and beta parvalbumins. Structure and tissue-specific expression. Eur J Biochem. 1993 Aug 1;215(3):719-27. PMID:8354278
  3. ↑ Lim DL, Neo KH, Yi FC, Chua KY, Goh DL, Shek LP, Giam YC, Van Bever HP, Lee BW. Parvalbumin--the major tropical fish allergen. Pediatr Allergy Immunol. 2008 Aug;19(5):399-407. doi:, 10.1111/j.1399-3038.2007.00674.x. Epub 2008 Jan 25. PMID:18221468 doi:http://dx.doi.org/10.1111/j.1399-3038.2007.00674.x
  4. ↑ Declercq JP, Evrard C, Lamzin V, Parello J. Crystal structure of the EF-hand parvalbumin at atomic resolution (0.91 A) and at low temperature (100 K). Evidence for conformational multistates within the hydrophobic core. Protein Sci. 1999 Oct;8(10):2194-204. PMID:10548066

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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