Peptidyl-tRNA hydrolase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:50, 5 January 2025) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
<StructureSection load='' size='350' side='right' caption='Structure of peptidyl-tRNA hydrolase complex with tRNA CCA acceptor domain (PDB entry [[3vjr]])' scene='55/551222/Cv/1'>
<StructureSection load='' size='350' side='right' caption='Structure of peptidyl-tRNA hydrolase complex with tRNA CCA acceptor domain (PDB entry [[3vjr]])' scene='55/551222/Cv/1'>
== Function ==
== Function ==
-
'''Peptidyl-tRNA hydrolase''' (PTH) is a bacterial enzyme which cleaves peptidyl-tRNA to free peptide and tRNA<ref>PMID:16849786</ref>. PTH catalyzes the reaction in cases of aborted translation for recycling the tRNA for further rounds of protein synthesis. PTH is essential for bacterial viability.
+
'''Peptidyl-tRNA hydrolase''' (PTH) is a bacterial enzyme which cleaves peptidyl-tRNA to free peptide and tRNA<ref>PMID:16849786</ref>. PTH catalyzes the reaction in cases of aborted translation for recycling the tRNA for further rounds of protein synthesis. PTH is essential for bacterial viability.rew)]].
 +
 
 +
See also [[Peptidyl-tRNA hydrolase 2, mitochondrial (Hebrew)]].
== Structural highlights ==
== Structural highlights ==
-
PTH dimer interacts with tRNA at the latter's <scene name='55/551222/Cv/2'>CCA - the 3' end of the molecule which binds the amino acid</scene>; the <scene name='55/551222/Cv/3'>acceptor site which pass-pairs tRNA N-terminal nucleotides to the C-terminal nucleotides</scene> and the TΨC site (Ψ is pseudouridine) which is the <scene name='55/551222/Cv/4'>tRNA ribosome recognition site</scene><ref>PMID:22923517</ref>.
+
PTH dimer interacts with tRNA at the latter's <scene name='55/551222/Cv/5'>CCA - the 3' end of the molecule which binds the amino acid</scene>; the <scene name='55/551222/Cv/6'>acceptor site which pass-pairs tRNA N-terminal nucleotides to the C-terminal nucleotides</scene> and the TΨC site (Ψ is pseudouridine) which is the <scene name='55/551222/Cv/7'>tRNA ribosome recognition site</scene><ref>PMID:22923517</ref>.
</StructureSection>
</StructureSection>
Line 14: Line 16:
*Peptidyl-tRNA hydrolase
*Peptidyl-tRNA hydrolase
 +
**[[1q7s]] – hPTH residues 63-179– human<BR />
**[[2pth]] – EcPTH – ''Escherichia coli''<BR />
**[[2pth]] – EcPTH – ''Escherichia coli''<BR />
**[[3ofv]] – EcPTH (mutant)<BR />
**[[3ofv]] – EcPTH (mutant)<BR />
Line 28: Line 31:
**[[3v2i]] – PTH – ''Burkholderia thailandesis''<BR />
**[[3v2i]] – PTH – ''Burkholderia thailandesis''<BR />
**[[4dhw]], [[4djj]], [[4erx]], [[4fno]], [[4fyj]], [[4jc4]], [[4qaj]] – PaPTH – ''Pseudomonas aeruginosa''<BR />
**[[4dhw]], [[4djj]], [[4erx]], [[4fno]], [[4fyj]], [[4jc4]], [[4qaj]] – PaPTH – ''Pseudomonas aeruginosa''<BR />
-
**[[4fop]], [[4fot]], [[4hoy]], [[4iko]], [[4jy7]], [[5y98]], [[4lwq]] – AbPTH – ''Acinetobacter baumannii''<BR />
+
**[[4fop]], [[4fot]], [[4hoy]], [[4iko]], [[4jy7]], [[5y98]], [[4lwq]], [[5yl8]], [[5yla]], [[5yn4]], [[5zzv]], [[6a31]], [[6ivv]], [[6iye]], [[6j93]], [[6jgu]], [[6jj1]], [[6jjq]], [[6jkx]], [[6jqt]], [[6jk8]], [[6kl8]], [[6lso]], [[6lsp]], [[7csn]] - AbPTH – ''Acinetobacter baumannii''<BR />
-
**[[4olj]] – AbPTH (mutant)<BR />
+
**[[4olj]], [[6ix6]] – AbPTH (mutant)<BR />
**[[4p7b]] – PTH – ''Salmonella enterica''<BR />
**[[4p7b]] – PTH – ''Salmonella enterica''<BR />
**[[2mjl]], [[4zxp]], [[5ivp]], [[5gvz]] – VcPTH – ''Vibrio cholerae''<BR />
**[[2mjl]], [[4zxp]], [[5ivp]], [[5gvz]] – VcPTH – ''Vibrio cholerae''<BR />
-
**[[4z86]], [[5b6j]], [[5ekt]], [[5ike]], [[5imb]] – VcPTH (mutant)<BR />
+
**[[4z86]], [[5b6j]], [[5ekt]], [[5ike]], [[5imb]], [[5zk0]] – VcPTH (mutant)<BR />
**[[4qt4]] – PTH – ''Streptococcus pyogenes''<BR />
**[[4qt4]] – PTH – ''Streptococcus pyogenes''<BR />
**[[4yly]] – PTH – ''Streptococcus aureus''<BR />
**[[4yly]] – PTH – ''Streptococcus aureus''<BR />
 +
**[[5zx8]] – PTH – ''Thermus thermophilus''<BR />
 +
**[[7brd]] – PTH – ''Klebsiella pneumoniae''<BR />
*Peptidyl-tRNA hydrolase complex
*Peptidyl-tRNA hydrolase complex
Line 43: Line 48:
**[[4jx9]] – AbPTH + uridine<BR />
**[[4jx9]] – AbPTH + uridine<BR />
**[[4qbk]] – PaPTH + adenosine derivative<BR />
**[[4qbk]] – PaPTH + adenosine derivative<BR />
 +
**[[8axp]] – PTH + thyazole derivative – ''Neisseria gonorrhoeae''<BR />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of peptidyl-tRNA hydrolase complex with tRNA CCA acceptor domain (PDB entry 3vjr)

Drag the structure with the mouse to rotate

3D Structures of peptidyl-tRNA hydrolase

Updated on 05-January-2025

References

  1. ↑ Das G, Varshney U. Peptidyl-tRNA hydrolase and its critical role in protein biosynthesis. Microbiology. 2006 Aug;152(Pt 8):2191-5. PMID:16849786 doi:http://dx.doi.org/10.1099/mic.0.29024-0
  2. ↑ Ito K, Murakami R, Mochizuki M, Qi H, Shimizu Y, Miura KI, Ueda T, Uchiumi T. Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase. Nucleic Acids Res. 2012 Aug 25. PMID:22923517 doi:10.1093/nar/gks790

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Peptidyl-tRNA_hydrolase"
Personal tools