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5ow3

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==Crystal structure of a C-terminally truncated trimeric ectodomain of the Arabidopsis thaliana gamete fusion protein HAP2==
==Crystal structure of a C-terminally truncated trimeric ectodomain of the Arabidopsis thaliana gamete fusion protein HAP2==
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<StructureSection load='5ow3' size='340' side='right' caption='[[5ow3]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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<StructureSection load='5ow3' size='340' side='right'caption='[[5ow3]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ow3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OW3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ow3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OW3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ow3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ow3 OCA], [http://pdbe.org/5ow3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ow3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ow3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ow3 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ow3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ow3 OCA], [https://pdbe.org/5ow3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ow3 RCSB], [https://www.ebi.ac.uk/pdbsum/5ow3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ow3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HAP2_ARATH HAP2_ARATH]] Required for male fertility (PubMed:17079265, PubMed:20333238). Plays a role in pollen tube guidance and successful gamete attachment (PubMed:17079265). Essential for the fusion of gametes during double fertilization, where one male gamete fuses with the egg to produce a zygote, and another male gamete fuses with the central cell to produce the endosperm (PubMed:17079265, PubMed:20333238, PubMed:21209845). Mediates the fusion of cell membranes (PubMed:28137780). Not required for pollen tube outgrowth (PubMed:17079265, PubMed:20333238).<ref>PMID:16378100</ref> <ref>PMID:17079265</ref> <ref>PMID:20333238</ref> <ref>PMID:21209845</ref> <ref>PMID:23180860</ref> <ref>PMID:28137780</ref>
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[https://www.uniprot.org/uniprot/HAP2_ARATH HAP2_ARATH] Required for male fertility (PubMed:17079265, PubMed:20333238). Plays a role in pollen tube guidance and successful gamete attachment (PubMed:17079265). Essential for the fusion of gametes during double fertilization, where one male gamete fuses with the egg to produce a zygote, and another male gamete fuses with the central cell to produce the endosperm (PubMed:17079265, PubMed:20333238, PubMed:21209845). Mediates the fusion of cell membranes (PubMed:28137780). Not required for pollen tube outgrowth (PubMed:17079265, PubMed:20333238).<ref>PMID:16378100</ref> <ref>PMID:17079265</ref> <ref>PMID:20333238</ref> <ref>PMID:21209845</ref> <ref>PMID:23180860</ref> <ref>PMID:28137780</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fedry, J]]
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[[Category: Arabidopsis thaliana]]
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[[Category: Krey, T]]
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[[Category: Large Structures]]
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[[Category: Legrand, P]]
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[[Category: Fedry J]]
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[[Category: Rey, F A]]
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[[Category: Krey T]]
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[[Category: Class ii fold]]
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[[Category: Legrand P]]
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[[Category: Gamete fusion protein]]
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[[Category: Rey FA]]
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[[Category: Hap2]]
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[[Category: Membrane fusion]]
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[[Category: Membrane protein]]
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Current revision

Crystal structure of a C-terminally truncated trimeric ectodomain of the Arabidopsis thaliana gamete fusion protein HAP2

PDB ID 5ow3

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