2p1y

From Proteopedia

(Difference between revisions)

Current revision

1.B2.D9, a bispecific alpha/beta TCR

Structural highlights

2p1y is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.42Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q5R1B3_MOUSE

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

We report crystal structures of a negatively selected T cell receptor (TCR) that recognizes two I-A(u)-restricted myelin basic protein peptides and one of its peptide/major histocompatibility complex (pMHC) ligands. Unusual complementarity-determining region (CDR) structural features revealed by our analyses identify a previously unrecognized mechanism by which the highly variable CDR3 regions define ligand specificity. In addition to the pMHC contact residues contributed by CDR3, the CDR3 residues buried deep within the V alpha/V beta interface exert indirect effects on recognition by influencing the V alpha/V beta interdomain angle. This phenomenon represents an additional mechanism for increasing the potential diversity of the TCR repertoire. Both the direct and indirect effects exerted by CDR residues can impact global TCR/MHC docking. Analysis of the available TCR structures in light of these results highlights the significance of the V alpha/V beta interdomain angle in determining specificity and indicates that TCR/pMHC interface features do not distinguish autoimmune from non-autoimmune class II-restricted TCRs.

A new twist in TCR diversity revealed by a forbidden alphabeta TCR.,McBeth C, Seamons A, Pizarro JC, Fleishman SJ, Baker D, Kortemme T, Goverman JM, Strong RK J Mol Biol. 2008 Feb 1;375(5):1306-19. Epub 2007 Nov 17. PMID:18155234^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ McBeth C, Seamons A, Pizarro JC, Fleishman SJ, Baker D, Kortemme T, Goverman JM, Strong RK. A new twist in TCR diversity revealed by a forbidden alphabeta TCR. J Mol Biol. 2008 Feb 1;375(5):1306-19. Epub 2007 Nov 17. PMID:18155234 doi:10.1016/j.jmb.2007.11.020

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2p1y"

Categories: Large Structures | Mus musculus | McBeth C | Pizarro JC | Strong RK

@@ Line 1: / Line 1: @@
 ==1.B2.D9, a bispecific alpha/beta TCR==
-<StructureSection load='2p1y' size='340' side='right' caption='[[2p1y]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
+<StructureSection load='2p1y' size='340' side='right'caption='[[2p1y]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2p1y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P1Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P1Y FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2p1y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P1Y FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2p24|2p24]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.42&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Valpha2.3/Vbeta8.2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p1y OCA], [https://pdbe.org/2p1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p1y RCSB], [https://www.ebi.ac.uk/pdbsum/2p1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p1y ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p1y OCA], [http://pdbe.org/2p1y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p1y RCSB], [http://www.ebi.ac.uk/pdbsum/2p1y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p1y ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q5R1B3_MOUSE Q5R1B3_MOUSE]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 13: / Line 14: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p1/2p1y_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 29: / Line 30: @@
 ==See Also==
-*[[T-cell receptor|T-cell receptor]]
+*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Lk3 transgenic mice]]
+[[Category: Large Structures]]
-[[Category: McBeth, C]]
+[[Category: Mus musculus]]
-[[Category: Pizarro, J C]]
+[[Category: McBeth C]]
-[[Category: Strong, R K]]
+[[Category: Pizarro JC]]
-[[Category: Autoimmunity]]
+[[Category: Strong RK]]
-[[Category: Diabody]]
-[[Category: Immune system]]
-[[Category: Immunoglobulin fold]]
-[[Category: Tcr]]

2p1y

From Proteopedia

Current revision

1.B2.D9, a bispecific alpha/beta TCR

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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