2orx

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==Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin==
==Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin==
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<StructureSection load='2orx' size='340' side='right' caption='[[2orx]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='2orx' size='340' side='right'caption='[[2orx]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2orx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ORX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2orx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ORX FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nrp1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2orx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orx OCA], [http://pdbe.org/2orx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2orx RCSB], [http://www.ebi.ac.uk/pdbsum/2orx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2orx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2orx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orx OCA], [https://pdbe.org/2orx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2orx RCSB], [https://www.ebi.ac.uk/pdbsum/2orx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2orx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NRP1_RAT NRP1_RAT]] Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis (By similarity).
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[https://www.uniprot.org/uniprot/NRP1_RAT NRP1_RAT] Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/2orx_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/2orx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Large Structures]]
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[[Category: Bellamy, H D]]
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[[Category: Rattus norvegicus]]
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[[Category: Jusino, M A]]
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[[Category: Bellamy HD]]
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[[Category: Kooi, C W.Vander]]
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[[Category: Jusino MA]]
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[[Category: Leahy, D J]]
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[[Category: Leahy DJ]]
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[[Category: Neau, D B]]
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[[Category: Neau DB]]
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[[Category: Perman, B]]
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[[Category: Perman B]]
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[[Category: Membrane protein]]
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[[Category: Vander Kooi CW]]
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[[Category: Neuropilin]]
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[[Category: Signaling protein]]
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[[Category: Tuftsin]]
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[[Category: Vegf]]
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Current revision

Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin

PDB ID 2orx

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