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| | ==Crystal structure of protein AF2318 from Archaeglobus fulgidus, Pfam DUF54== | | ==Crystal structure of protein AF2318 from Archaeglobus fulgidus, Pfam DUF54== |
| - | <StructureSection load='2ogk' size='340' side='right' caption='[[2ogk]], [[Resolution|resolution]] 3.00Å' scene=''> | + | <StructureSection load='2ogk' size='340' side='right'caption='[[2ogk]], [[Resolution|resolution]] 3.00Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2ogk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfl Arcfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OGK FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2ogk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OGK FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AF_2318 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 ARCFL])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ogk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ogk OCA], [http://pdbe.org/2ogk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ogk RCSB], [http://www.ebi.ac.uk/pdbsum/2ogk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ogk ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/2ogk TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ogk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ogk OCA], [https://pdbe.org/2ogk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ogk RCSB], [https://www.ebi.ac.uk/pdbsum/2ogk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ogk ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2ogk TOPSAN]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/O27966_ARCFU O27966_ARCFU] |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Arcfl]] | + | [[Category: Archaeoglobus fulgidus]] |
| - | [[Category: Burley, S K]] | + | [[Category: Large Structures]] |
| - | [[Category: Structural genomic]] | + | [[Category: Burley SK]] |
| - | [[Category: Rao, K N]] | + | [[Category: Rao KN]] |
| - | [[Category: Swaminathan, S]] | + | [[Category: Swaminathan S]] |
| - | [[Category: Archaeglobus fulgidus]]
| + | |
| - | [[Category: Conserved hypothetical protein]]
| + | |
| - | [[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
| + | |
| - | [[Category: PSI, Protein structure initiative]]
| + | |
| - | [[Category: Unknown function]]
| + | |
| Structural highlights
Function
O27966_ARCFU
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
We have determined X-ray crystal structures of four members of an archaeal specific family of proteins of unknown function (UPF0201; Pfam classification: DUF54) to advance our understanding of the genetic repertoire of archaea. Despite low pairwise amino acid sequence identities (10-40%) and the absence of conserved sequence motifs, the three-dimensional structures of these proteins are remarkably similar to one another. Their common polypeptide chain fold, encompassing a five-stranded antiparallel beta-sheet and five alpha-helices, proved to be quite unexpectedly similar to that of the RRM-type RNA-binding domain of the ribosomal L5 protein, which is responsible for binding the 5S- rRNA. Structure-based sequence alignments enabled construction of a phylogenetic tree relating UPF0201 family members to L5 ribosomal proteins and other structurally similar RNA binding proteins, thereby expanding our understanding of the evolutionary purview of the RRM superfamily. Analyses of the surfaces of these newly determined UPF0201 structures suggest that they probably do not function as RNA binding proteins, and that this domain specific family of proteins has acquired a novel function in archaebacteria, which awaits experimental elucidation.
UPF201 archaeal specific family members reveal structural similarity to RNA-binding proteins but low likelihood for RNA-binding function.,Rao KN, Burley SK, Swaminathan S PLoS ONE. 2008;3(12):e3903. Epub 2008 Dec 11. PMID:19079550[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Rao KN, Burley SK, Swaminathan S. UPF201 archaeal specific family members reveal structural similarity to RNA-binding proteins but low likelihood for RNA-binding function. PLoS ONE. 2008;3(12):e3903. Epub 2008 Dec 11. PMID:19079550 doi:10.1371/journal.pone.0003903
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