This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Potassium channel toxin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:51, 26 January 2022) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 3: Line 3:
== Function ==
== Function ==
'''Potassium channel toxins''' are various venoms which block the transport of potassium ions across the plasma membrane through potassium channels<ref>PMID:2181489</ref>.
'''Potassium channel toxins''' are various venoms which block the transport of potassium ions across the plasma membrane through potassium channels<ref>PMID:2181489</ref>.
 +
 +
See also [[Vm24 Scorpion Toxin]].
==Overview==
==Overview==
Line 17: Line 19:
NMR studies of LqhαIT with a peptide derived from part of neurotoxin receptor site-3 (D4S3-S4) identified residues <scene name='1lqh/Nmr/1'>Lys8, Asn9, Cys12, Val13, Arg18, Trp38, Ala39 and Arg58</scene> of LqhαIT as participating in binding to that extra-cellular part of the sodium channel (3).
NMR studies of LqhαIT with a peptide derived from part of neurotoxin receptor site-3 (D4S3-S4) identified residues <scene name='1lqh/Nmr/1'>Lys8, Asn9, Cys12, Val13, Arg18, Trp38, Ala39 and Arg58</scene> of LqhαIT as participating in binding to that extra-cellular part of the sodium channel (3).
Both methods led to the identification of two regions on the surface of LqhαIT that participate in binding of the toxin to neurotoxin receptor site-3 on sodium channels.
Both methods led to the identification of two regions on the surface of LqhαIT that participate in binding of the toxin to neurotoxin receptor site-3 on sodium channels.
-
</StructureSection>
 
==3D structures of potassium channel toxins==
==3D structures of potassium channel toxins==
 +
[[Potassium channel toxin 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
 
+
-
*Scorpion toxins
+
-
 
+
-
**[[1pnh]] – PO5-NH2 – NMR<BR />
+
-
**[[1ktx]], [[2ktx]], [[1xsw]], [[2uvs]], [[2k4u]], [[1bkt]] – kaliotoxin – NMR<BR />
+
-
**[[2mla]], [[2mld]] - kaliotoxin (mutant) – NMR<br />
+
-
**[[3odv]] - kaliotoxin<br />
+
-
**[[1sxm]] – noxiustoxin – NMR<BR />
+
-
**[[1sco]] – lenatoxin – NMR<BR />
+
-
**[[1acw]] – P01 – NMR<BR />
+
-
**[[1txm]] – maurotoxin – NMR<BR />
+
-
**[[1tsk]] – TS kappa – NMR<BR />
+
-
**[[2pta]] – PITX-KA – NMR<BR />
+
-
**[[1c49]] – PITX-KB – NMR<BR />
+
-
**[[2ktc]] – BT BTK-2 - NMR<BR />
+
-
**[[1quz]], [[1wpd]], [[1y2p]] – HSTX1 – NMR<BR />
+
-
**[[1wmt]] - ISTX – NMR<BR />
+
-
**[[1wqc]] – OMTX1 – NMR<BR />
+
-
**[[1wqd]] – OMTX2 – NMR<br />
+
-
**[[1wqe]] – OMTX3 – NMR<BR />
+
-
**[[2ck4]], [[2ck5]] – OSK1 – NMR<BR />
+
-
**[[2jp6]] – TC32 - NMR<BR />
+
-
**[[1rji]] - BMKX – NMR<BR />
+
-
**[[1big]] – BMTX1 – NMR<BR />
+
-
**[[1s8k]] – BMKK4 - NMR<BR />
+
-
**[[1q2k]], [[1r1g]] – BMK37 – NMR<BR />
+
-
**[[3e8y]] – BMK37<br />
+
-
**[[2bmt]] – BMTX2 – NMR<BR />
+
-
**[[1m2s]] – BMTX3 – NMR<BR />
+
-
**[[1qky]] – PI7 – NMR<BR />
+
-
**[[1n8m]] – Pi4 – NMR<BR />
+
-
**[[1wz5]] – Pi1 – NMR<BR />
+
-
**[[2k9o]] – VM24 - NMR<BR />
+
-
**[[1wm7]] - BMP01 – NMR<BR />
+
-
**[[1du9]] – BMP02 – NMR<BR />
+
-
**[[1wm8]] - BMP03 – NMR<BR />
+
-
**[[1pvz]] - BMP07 – NMR<BR />
+
-
**[[1j5j]], [[1lgl]] – BEKM-1 – NMR<BR />
+
-
**[[2li3]] – κ-KTX 3.1 - NMR<BR />
+
-
**[[6ats]] - κ-KTX 1.2<br />
+
-
**[[6avc]] - α-KTX 1.5<br />
+
-
**[[6ay7]] - α-KTX 3.5<br />
+
-
**[[6atl]] - α-KTX 4.2<br />
+
-
**[[6atn]] - α-KTX 4.5<br />
+
-
**[[6atm]] - α-KTX 3.10<br />
+
-
**[[6avd]] - α-KTX 6.9<br />
+
-
**[[6ay8]] - α-KTX 15.8<br />
+
-
**[[6au7]], [[6aup]] - γ-KTX 2.2<br />
+
-
**[[1hp9]] – κ-hefutoxin 1 – NMR<BR />
+
-
**[[1ne5]], [[1px9]] – ergtoxin - NMR<BR />
+
-
**[[1hp2]] – tityustoxin K α – NMR<BR />
+
-
**[[1jlz]] - tityustoxin α KTX – NMR<BR />
+
-
**[[1scy]] – scyllatoxin – NMR<BR />
+
-
**[[1hly]] – hongotoxin - NMR<BR />
+
-
**[[1c55]], [[1c56]], [[1wt7]] – butantoxin – NMR<BR />
+
-
**[[2axk]] – discrepin - NMR<BR />
+
-
**[[1agt]] – agitoxin – NMR<BR />
+
-
**[[1pjv]] – cobatoxin - NMR<BR />
+
-
**[[1mtx]]– margatoxin – NMR<BR />
+
-
**[[2kfe]] – meucin-24 – NMR<BR />
+
-
**[[2ky3]], [[2lu9]] – tamapin - NMR<BR />
+
-
**[[2me7]], [[2mel]], [[2men]], [[2meo]] – tamapin (mutant) – NMR<br />
+
-
**[[1bah]], [[2crd]] – charybdotoxin - NMR<br />
+
-
**[[1cmr]] – charybdotoxin (mutant) - NMR<br />
+
-
**[[4jta]], [[4jtc]], [[4jtd]] – charybdotoxin + voltage-gated potassium channel β2<br />
+
-
**[[2a9h]] – charybdotoxin + voltage-gated potassium channel β2 - NMR<br />
+
-
**[[1lir]] – LQ2 – NMR<br />
+
-
**[[2sn3]] – toxin – Centruroides exilicauda<br />
+
-
**[[1ptx]] – toxin – Androctonus australis<br />
+
-
**[[1lqh]], [[1lqi]] – toxin α – NMR<br />
+
-
**[[1snb]] – MmBMK M8 – Mesobuthus martensii<br />
+
-
**[[1sn1]] - MmBMK M1<br />
+
-
**[[2lix]] – IMKTX104 – NMR<br />
+
-
**[[2rtz]] – MARKTX-7 – NMR<br />
+
-
 
+
-
*Sea anemone toxins
+
-
**[[1bgk]] – BGK – NMR<br />
 
-
**[[1roo]] – SHK – NMR<br />
 
-
**[[4lfs]], [[4z7p]] – SHK (mutant)<br />
 
-
**[[1bei]], [[1c2u]], [[2k9e]] – SHK (mutant) – NMR<br />
 
-
**[[4lfq]], [[4lfs]], [[5i5a]], [[5i5b]], [[5i5c]] – SHK<br />
 
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Scorpion potassium channel toxin, 1lqh

Drag the structure with the mouse to rotate

References

  1. ↑ Strong PN. Potassium channel toxins. Pharmacol Ther. 1990;46(1):137-62. PMID:2181489

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

Retrieved from "http://52.214.119.220/wiki/index.php/Potassium_channel_toxin"
Personal tools