6ea9
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of VACV Poxin in post-reactive state with Gp[2'-5']Ap[3']== | |
| - | + | <StructureSection load='6ea9' size='340' side='right'caption='[[6ea9]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ea9]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_WR Vaccinia virus WR]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EA9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9BG:2,5-GpAp'>9BG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ea9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ea9 OCA], [https://pdbe.org/6ea9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ea9 RCSB], [https://www.ebi.ac.uk/pdbsum/6ea9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ea9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/POXIN_VACCW POXIN_VACCW] Nuclease that is responsible for viral evasion of host cGAS-STING innate immunity (PubMed:30728498). Cleaves 2',3'-cGAMP which is produced by host cGAS following recognition of cytosolic DNA and blocks the subsequent 2',3'-cGAMP-mediated activation of TMEM173/STING, which normally spreads to adjacent cells and activates the interferon and NF-kappa-B immune responses (PubMed:30728498).<ref>PMID:30728498</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Vaccinia virus WR]] | ||
| + | [[Category: Eaglesham JB]] | ||
| + | [[Category: Kranzusch PJ]] | ||
Current revision
Structure of VACV Poxin in post-reactive state with Gp[2'-5']Ap[3']
| |||||||||||
