2pbr

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[[Image:2pbr.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5==
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|PDB= 2pbr |SIZE=350|CAPTION= <scene name='initialview01'>2pbr</scene>, resolution 1.96&Aring;
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<StructureSection load='2pbr' size='340' side='right'caption='[[2pbr]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[2pbr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PBR FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pbr OCA], [https://pdbe.org/2pbr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pbr RCSB], [https://www.ebi.ac.uk/pdbsum/2pbr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pbr ProSAT], [https://www.topsan.org/Proteins/RSGI/2pbr TOPSAN]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pbr OCA], [http://www.ebi.ac.uk/pdbsum/2pbr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pbr RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/KTHY_AQUAE KTHY_AQUAE] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pb/2pbr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pbr ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5'''
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==See Also==
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*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2PBR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PBR OCA].
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[[Category: Aquifex aeolicus VF5]]
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[[Category: Aquifex aeolicus]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Ebihara A]]
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[[Category: dTMP kinase]]
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[[Category: Jeyakanthan J]]
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[[Category: Ebihara, A.]]
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[[Category: Kanaujia SP]]
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[[Category: Jeyakanthan, J.]]
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[[Category: Kuramitsu S]]
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[[Category: Kanaujia, S P.]]
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[[Category: Nakagawa N]]
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[[Category: Kuramitsu, S.]]
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[[Category: Sekar K]]
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[[Category: Nakagawa, N.]]
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[[Category: Shinkai A]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Shiro Y]]
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[[Category: Ranjani, C Vasuki.]]
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[[Category: Vasuki Ranjani C]]
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[[Category: Sekar, K.]]
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[[Category: Yokoyama S]]
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[[Category: Shinkai, A.]]
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[[Category: Shiro, Y.]]
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[[Category: Yokoyama, S.]]
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[[Category: atp-binding]]
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[[Category: kinase]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nppsfa]]
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[[Category: nucleotide biosynthesis]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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[[Category: tmp-binding]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:34:01 2008''
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Current revision

Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5

PDB ID 2pbr

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