This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6hf7
From Proteopedia
(Difference between revisions)
m (Protected "6hf7" [edit=sysop:move=sysop]) |
|||
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the adenylate kinase from Methanothermococcus thermolithotrophicus co-crystallized with Tb-Xo4== | |
| + | <StructureSection load='6hf7' size='340' side='right'caption='[[6hf7]], [[Resolution|resolution]] 1.96Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6hf7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermococcus_thermolithotrophicus Methanothermococcus thermolithotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HF7 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7MT:Tb-Xo4'>7MT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TB:TERBIUM(III)+ION'>TB</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hf7 OCA], [http://pdbe.org/6hf7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hf7 RCSB], [http://www.ebi.ac.uk/pdbsum/6hf7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hf7 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Obtaining crystals and solving the phase problem remain major hurdles encountered by bio-crystallographers in their race to obtain new high-quality structures. Both issues can be overcome by the crystallophore, Tb-Xo4, a lanthanide-based molecular complex with unique nucleating and phasing properties. This article presents examples of new crystallization conditions induced by the presence of Tb-Xo4. These new crystalline forms bypass crystal defects often encountered by crystallographers, such as low-resolution diffracting samples or crystals with twinning. Thanks to Tb-Xo4's high phasing power, the structure determination process is greatly facilitated and can be extended to serial crystallography approaches. | ||
| - | + | Protein crystal structure determination with the crystallophore, a nucleating and phasing agent.,Engilberge S, Wagner T, Santoni G, Breyton C, Shima S, Franzetti B, Riobe F, Maury O, Girard E J Appl Crystallogr. 2019 Jun 28;52(Pt 4):722-731. doi: 10.1107/S1600576719006381., eCollection 2019 Aug 1. PMID:31396026<ref>PMID:31396026</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 6hf7" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Adenylate kinase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Methanothermococcus thermolithotrophicus]] | ||
[[Category: Breyton, C]] | [[Category: Breyton, C]] | ||
| + | [[Category: Engilberge, S]] | ||
[[Category: Franzetti, B]] | [[Category: Franzetti, B]] | ||
| + | [[Category: Girard, E]] | ||
| + | [[Category: Maury, O]] | ||
| + | [[Category: Riobe, F]] | ||
[[Category: Santoni, G]] | [[Category: Santoni, G]] | ||
| - | [[Category: | + | [[Category: Shima, S]] |
| + | [[Category: Wagner, T]] | ||
| + | [[Category: Crystallophore]] | ||
| + | [[Category: De novo phasing]] | ||
| + | [[Category: Lanthanide complex]] | ||
| + | [[Category: Molecular glue]] | ||
| + | [[Category: Nucleation]] | ||
| + | [[Category: Protein crystallization]] | ||
| + | [[Category: Tb-xo4]] | ||
| + | [[Category: Transferase]] | ||
Current revision
Crystal structure of the adenylate kinase from Methanothermococcus thermolithotrophicus co-crystallized with Tb-Xo4
| |||||||||||
Categories: Adenylate kinase | Large Structures | Methanothermococcus thermolithotrophicus | Breyton, C | Engilberge, S | Franzetti, B | Girard, E | Maury, O | Riobe, F | Santoni, G | Shima, S | Wagner, T | Crystallophore | De novo phasing | Lanthanide complex | Molecular glue | Nucleation | Protein crystallization | Tb-xo4 | Transferase
