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6hgw
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6hgw is ON HOLD Authors: Kramer, J.S., Pogoryelov, D., Hiesinger, K., Proschak, E. Description: Soluble epoxide hydrolase in complex with 2-(4-fluo...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Soluble epoxide hydrolase in complex with 2-(4-fluorophenyl)-N-(4-phenoxybenzyl)ethanamine== | |
| - | + | <StructureSection load='6hgw' size='340' side='right'caption='[[6hgw]], [[Resolution|resolution]] 2.41Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hgw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HGW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HGW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G3W:2-(4-fluorophenyl)-~{N}-[(4-phenoxyphenyl)methyl]ethanamine'>G3W</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hgw OCA], [http://pdbe.org/6hgw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hgw RCSB], [http://www.ebi.ac.uk/pdbsum/6hgw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hgw ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN]] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Hiesinger, K]] | [[Category: Hiesinger, K]] | ||
| + | [[Category: Kramer, J S]] | ||
[[Category: Pogoryelov, D]] | [[Category: Pogoryelov, D]] | ||
| - | [[Category: | + | [[Category: Proschak, E]] |
| + | [[Category: Complex]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Seh]] | ||
Current revision
Soluble epoxide hydrolase in complex with 2-(4-fluorophenyl)-N-(4-phenoxybenzyl)ethanamine
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Categories: Large Structures | Hiesinger, K | Kramer, J S | Pogoryelov, D | Proschak, E | Complex | Hydrolase | Inhibitor | Seh
