6m8h
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6m8h is ON HOLD Authors: Mascarenhas, R., Goossens, J., Leverson, B., Kothawala, S., Ballicora, M., Olsen, K., de freitas, D., Liu, D. Description:...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the R208Q mutant of G(i) subunit alpha-1== | |
| - | + | <StructureSection load='6m8h' size='340' side='right'caption='[[6m8h]], [[Resolution|resolution]] 2.07Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6m8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M8H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m8h OCA], [https://pdbe.org/6m8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m8h RCSB], [https://www.ebi.ac.uk/pdbsum/6m8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m8h ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Ballicora M]] | ||
| + | [[Category: Goossens J]] | ||
| + | [[Category: Kothawala S]] | ||
| + | [[Category: Leverson B]] | ||
| + | [[Category: Liu D]] | ||
| + | [[Category: Mascarenhas R]] | ||
| + | [[Category: Olsen K]] | ||
| + | [[Category: De freitas D]] | ||
Current revision
Crystal Structure of the R208Q mutant of G(i) subunit alpha-1
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