6d7l

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==Cytoplasmic domain of TRPC3==
==Cytoplasmic domain of TRPC3==
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<StructureSection load='6d7l' size='340' side='right' caption='[[6d7l]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
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<SX load='6d7l' size='340' side='right' viewer='molstar' caption='[[6d7l]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6d7l]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D7L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D7L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6d7l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D7L FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d7l OCA], [http://pdbe.org/6d7l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d7l RCSB], [http://www.ebi.ac.uk/pdbsum/6d7l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d7l ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d7l OCA], [https://pdbe.org/6d7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d7l RCSB], [https://www.ebi.ac.uk/pdbsum/6d7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d7l ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/TRPC3_HUMAN TRPC3_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/TRPC3_HUMAN TRPC3_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRPC3_HUMAN TRPC3_HUMAN]] Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.<ref>PMID:20095964</ref> <ref>PMID:8646775</ref> <ref>PMID:9417057</ref> <ref>PMID:9930701</ref>
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[https://www.uniprot.org/uniprot/TRPC3_HUMAN TRPC3_HUMAN] Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.<ref>PMID:20095964</ref> <ref>PMID:8646775</ref> <ref>PMID:9417057</ref> <ref>PMID:9930701</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Azumaya, C M]]
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[[Category: Homo sapiens]]
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[[Category: Cordero-Morales, J F]]
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[[Category: Large Structures]]
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[[Category: Nakagawa, T]]
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[[Category: Azumaya CM]]
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[[Category: Sierra-Valdez, F J]]
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[[Category: Cordero-Morales JF]]
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[[Category: Cerebellum]]
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[[Category: Nakagawa T]]
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[[Category: Ion channel]]
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[[Category: Sierra-Valdez FJ]]
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[[Category: Membrane protein]]
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[[Category: Moonwalker]]
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[[Category: Transport protein]]
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[[Category: Trp channel]]
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Current revision

Cytoplasmic domain of TRPC3

6d7l, resolution 4.00Å

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