2pgd

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[[Image:2pgd.jpg|left|200px]]
 
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{{Structure
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==THE STRUCTURE OF 6-PHOSPHOGLUCONATE DEHYDROGENASE REFINED AT 2 ANGSTROMS RESOLUTION==
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|PDB= 2pgd |SIZE=350|CAPTION= <scene name='initialview01'>2pgd</scene>, resolution 2.&Aring;
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<StructureSection load='2pgd' size='340' side='right'caption='[[2pgd]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[2pgd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1pgd 1pgd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PGD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PGD FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(decarboxylating) Phosphogluconate dehydrogenase (decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pgd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pgd OCA], [https://pdbe.org/2pgd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pgd RCSB], [https://www.ebi.ac.uk/pdbsum/2pgd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pgd ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pgd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pgd OCA], [http://www.ebi.ac.uk/pdbsum/2pgd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pgd RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/6PGD_SHEEP 6PGD_SHEEP] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pg/2pgd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pgd ConSurf].
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<div style="clear:both"></div>
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'''THE STRUCTURE OF 6-PHOSPHOGLUCONATE DEHYDROGENASE REFINED AT 2 ANGSTROMS RESOLUTION'''
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==See Also==
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*[[6-phosphogluconate dehydrogenase 3D structures|6-phosphogluconate dehydrogenase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The three-dimensional structure of ovine 6-phosphogluconate dehydrogenase, refined at 2.5 A resolution with a residual for all data of 18.5%, is reported. This model, based on improved diffraction data and a corrected sequence, supersedes that reported earlier. Each subunit of the dimer has three domains: a beta-alpha-beta domain binds NADP; an all alpha domain provides much of the dimer interface; the C-terminal tail burrows into the second subunit.
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[[Category: Large Structures]]
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==About this Structure==
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2PGD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. This structure supersedes the now removed PDB entry 1PGD. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PGD OCA].
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==Reference==
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The structure of 6-phosphogluconate dehydrogenase refined at 2.5 A resolution., Adams MJ, Gover S, Leaback R, Phillips C, Somers DO, Acta Crystallogr B. 1991 Oct 1;47 ( Pt 5):817-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1793548 1793548]
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[[Category: Ovis aries]]
[[Category: Ovis aries]]
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[[Category: Phosphogluconate dehydrogenase (decarboxylating)]]
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[[Category: Adams MJ]]
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[[Category: Single protein]]
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[[Category: Gover S]]
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[[Category: Adams, M J.]]
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[[Category: Phillips C]]
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[[Category: Gover, S.]]
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[[Category: Phillips, C.]]
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[[Category: oxidoreductase (choh(d)-nadp+(a))]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:35:32 2008''
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Current revision

THE STRUCTURE OF 6-PHOSPHOGLUCONATE DEHYDROGENASE REFINED AT 2 ANGSTROMS RESOLUTION

PDB ID 2pgd

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