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5mou

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==NMR spatial structure of alpha-mammal toxin BeM9==
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==NMR spatial structure of scorpion alpha-like toxin BeM9==
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<StructureSection load='5mou' size='340' side='right' caption='[[5mou]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='5mou' size='340' side='right'caption='[[5mou]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5mou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buthus_eupeus Buthus eupeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MOU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5mou]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_eupeus Mesobuthus eupeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MOU FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mou OCA], [http://pdbe.org/5mou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mou RCSB], [http://www.ebi.ac.uk/pdbsum/5mou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mou ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mou OCA], [https://pdbe.org/5mou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mou RCSB], [https://www.ebi.ac.uk/pdbsum/5mou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mou ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SCX9_MESEU SCX9_MESEU]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Has paralytic activity in mice.
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[https://www.uniprot.org/uniprot/SCX9_MESEU SCX9_MESEU] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Has paralytic activity in mice.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buthus eupeus]]
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[[Category: Large Structures]]
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[[Category: Arseniev, A S]]
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[[Category: Mesobuthus eupeus]]
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[[Category: Berkut, A A]]
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[[Category: Arseniev AS]]
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[[Category: Grishin, E V]]
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[[Category: Berkut AA]]
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[[Category: Kuldushev, N A]]
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[[Category: Grishin EV]]
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[[Category: Mineev, K S]]
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[[Category: Kuldushev NA]]
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[[Category: Vassilevski, A A]]
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[[Category: Mineev KS]]
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[[Category: Protein]]
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[[Category: Vassilevski AA]]
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[[Category: Protein neurotoxin]]
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Current revision

NMR spatial structure of scorpion alpha-like toxin BeM9

PDB ID 5mou

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OCA

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