Purine nucleoside phosphorylase

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== Structural highlights ==
== Structural highlights ==
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<scene name='57/573714/Cv/2'>Residues 241-265 of PNP act as a gate that opens upon substrate binding</scene>. The ribose binding site is composed of mostly hydrophobic side chains<ref>PMID:14680831</ref>. <scene name='57/573714/Cv/4'>Active site</scene>.
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<scene name='57/573714/Cv/5'>Residues 241-265 of PNP act as a gate that opens upon substrate binding</scene>. The ribose binding site is composed of mostly hydrophobic side chains<ref>PMID:14680831</ref>. <scene name='57/573714/Cv/6'>Active site</scene>.
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</StructureSection>
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==3D structures of purine nucleoside phosphorylase==
==3D structures of purine nucleoside phosphorylase==
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[[Purine nucleoside phosphorylase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*'''Purine nucleoside phosphorylase'''
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**[[1ula]], [[1m73]] – hPNP – human<br />
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**[[1pbn]] – bPNP – bovine<br />
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**[[1odk]], [[1odl]] – TtPNP – ''Thermus thermophilus'' <br />
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**[[1z33]] – TvPNP – ''Trichomonas vaginalis''<br />
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**[[1tcv]], [[1td1]], [[5cxs]] – SmPNP – ''Schistosoma masoni''<br />
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**[[2b94]] – PNP – ''Plasmodium knowlesi'' <br />
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**[[4mar]] – MrPNP – ''Meiothermus ruber''<br />
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**[[1ecp]], [[1oty]], [[1ou4]], [[1yqq]], [[1yqu]], [[1yr3]], [[3onv]], [[4rj2]], [[4ts3]], [[4ts9]] – EcPNP – ''Escherichia coli'' <br />
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**[[1otx]], [[1oum]], [[1ov6]], [[3opv]], [[4tta]], [[4tti]], [[4ttj]] – EcPNP (mutant)<br />
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**[[1vhj]] – VcPNP – ''Vibrio cholerae''<br />
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**[[1xe3]] – PNP – ''Bacillus anthracis''<br />
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**[[4d8v]], [[4d8x]], [[4d8y]], [[4d98]] – BsPNP – ''Bacillus subtilis''<br />
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**[[3tl6]] – EhPNP – ''Entamoeba histolica''<br />
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**[[3uav]] – BcPNP – ''Bacillus cereus''<br />
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**[[4lkr]] – PNP – ''Shewanella oneidensis''<br />
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**[[4tym]] – PNP – ''Streptococcus agalactiae'' <br />
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*Purine nucleoside phosphorylase binary complex with phosphate
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**[[1a9o]], [[3pnp]], [[4pnp]] – bPNP + phosphate<br />
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**[[1qe5]] – CePNP + phosphate - ''Cellulomonas''<br />
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**[[1tcu]] – SmPNP + phosphate <br />
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**[[3khs]] – PNP + phosphate – grouper iridovirus<br />
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**[[4gka]] – hPNP (mutant) + phosphate<br />
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**[[4m3n]] – MrPNP + phosphate <br />
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**[[3ooe]], [[3ooh]] – EcPNP + phosphate <br />
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**[[4ldn]] – PNP + phosphate – ''Vibrio fischeri''<br />
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**[[4m7w]] – PNP + phosphate – ''Leptotrichia buccalis''<br />
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**[[5mx4]], [[5mx6]], [[5mx8]], [[5lu0]] - PNP + phosphate - ''Helicobacter pylori''<br />
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*Purine nucleoside phosphorylase complex with guanine and guanine derivatives
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**[[1ulb]], [[1v2h]] – hPNP + guanine<br />
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**[[4ece]] – hPNP (mutant) + guanine<br />
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**[[1rfg]] – hPNP + guanosine<br />
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**[[1yry]], [[3iny]] – hPNP + guanine derivative <br />
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**[[1v48]], [[2ai1]], [[2ai3]], [[3fuc]] – bPNP + guanine derivative <br />
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**[[3e9z]] – SmPNP + guanine derivative <br />
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**[[3iex]] – SmPNP + guanosine<br />
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**[[1odj]] – TtPNP + guanosine<br />
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**[[4da0]], [[4da8]], [[4dae]] – BsPNP + guanosine derivative<br />
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**[[1vmk]] – PNP + guanine – ''Thermotoga maritima'' <br />
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**[[3iom]] – MtPNP + guanine derivative - ''Mycobacterium tuberculosis'' <br />
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**[[5i3c]] - EcPNP + guanine derivative <br />
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**[[1b8n]] – bPNP + guanine derivative + phosphate<br />
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**[[1c3x]] – CePNP + guanine derivative + phosphate<br />
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**[[1pwy]], [[1v41]], [[1v45]] – hPNP + antiviral drug <br />
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*Purine nucleoside phosphorylase complex with inosine and inosine derivatives
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**[[1rct]] – hPNP + inosine <br />
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**[[1a9q]], [[1a9s]] – bPNP + inosine <br />
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**[[3faz]] – SmPNP + inosine <br />
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**[[2ai2]] – bPNP + inosine derivative <br />
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**[[1z38]] – TvPNP + inosine <br />
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**[[3uax]] – BcPNP + inosine <br />
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**[[2bsx]] – PfPNP + inosine – ''Plasmodium falciparum''<br />
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**[[1z39]] – TvPNP + deoxyinosine <br />
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**[[1a9t]], [[1a9p]], [[4pnp]] – bPNP + deazainosine + phosphate<br />
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**[[1pr0]] - EcPNP + inosine + phosphate<br />
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**[[1v3q]] – hPNP + anti HIV drug <br />
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*Purine nucleoside phosphorylase complex with xanthine and xanthine derivatives
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**[[1pf7]], [[1rr6]], [[1rsz]], [[1rt9]], [[3k8o]], [[3k8q]] – hPNP + transition state analog <br />
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**[[2on6]] – hPNP (mutant) + transition state analog <br />
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**[[1vfn]], [[1a9r]] – bPNP + hypoxanthine<br />
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**[[3fnq]] – SmPNP + hypoxanthine<br />
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**[[3scz]] – MtPNP + hypoxanthine<br />
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**[[4dab]] – BsPNP + hypoxanthine<br />
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**[[4uc0]] – PNP + hypoxanthine – ''Agrobacterium vitis''<br />
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**[[5ifk]] - PNP + hypoxanthine - ''Kluyveromyces lactis''<br />
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**[[3enz]] – PfPNP + hypoxanthine + ribose + arsenate<br />
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**[[2a0w]], [[2a0x]], [[2a0y]], [[2oc4]], [[2oc9]] – hPNP (mutant) + hypoxanthine derivative <br />
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**[[5iu6]] - EcPNP + hypoxanthine derivative<br />
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**[[3odg]] – YpPNP + xanthine – ''Yersinia pseudotuberculosis''<br />
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**[[1b8o]], [[1g2o]] – bPNP + hypoxanthine derivative + phosphate<br />
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**[[3bgs]] – bPNP + transition state analog + phosphate<br />
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**[[2q7o]], [[3phb]] – hPNP + transition state analog + phosphate<br />
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**[[4ear]], [[4eb8]] – hPNP (mutant) + transition state analog + phosphate<br />
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**[[3mb8]] – PNP + transition state analog + phosphate – ''Toxoplasma gondii''<br />
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**[[1n3i]] – MtPNP + deazahypoxanthine + phosphate <br />
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**[[1i80]] – MtPNP + iminoribitol + deazahypoxanthine + phosphate <br />
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*Purine nucleoside phosphorylase complex with adenine and adenine derivatives
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**[[1odi]] – TtPNP + adenosine <br />
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**[[1z34]], [[1z35]] – TvPNP + adenosine derivative <br />
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**[[4ns1]] – PgPNP + adenosine derivative – ''Porphyromonas gingivalis''<br />
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**[[4nsn]] – PgPNP + adenine <br />
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**[[3ggs]] – hPNP (mutant) + adenosine derivative <br />
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**[[1z37]] – TvPNP + adenosine <br />
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**[[3e9r]] – SmPNP + adenine <br />
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**[[4dao]] – BsPNP + adenine <br />
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**[[3f8w]] – SmPNP + adenosine <br />
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**[[1vhw]] – VcPNP + adenosine <br />
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**[[3u40]] – EhPNP + adenosine <br />
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**[[4d9h]] – BsPNP + adenosine <br />
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**[[4dan]] – BsPNP + adenosine derivative<br />
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**[[2ac7]], [[3uaw]] – BcPNP + adenosine <br />
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**[[3uay]], [[3uaz]] – BcPNP (mutant) + adenosine <br />
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**[[4m1e]] – PNP + adenine – ''Planctomyces limnophilus''<br />
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**[[4lna]] – PNP + adenine + phosphate – ''Spirosoma linguale''<br />
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**[[1pk7]] - EcPNP + adenosine + phosphate<br />
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**[[1pk9]], [[1pke]], [[1pr5]], [[1pr6]], [[1pw7]] - EcPNP + adenosine derivative + phosphate<br />
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*Purine nucleoside phosphorylase complex with purine and purine derivatives
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**[[1lv8]], [[1lvu]], [[2qpl]] – bPNP + purine derivative <br />
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**[[3gb9]] – hPNP (mutant) + purine derivative <br />
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**[[1fxu]] – bPNP + purine derivative + phosphate<br />
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**[[1ovg]] - EcPNP (mutant) + purine derivative <br />
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**[[1pr2]], [[1pr4]] – EcPNP + purine derivative + phosphate<br />
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*Other purine nucleoside phosphorylase complexes
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**[[3d1v]] – hPNP + mercapto-quinazolinone<br />
 
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**[[5etj]], [[5ugf]] - hPNP (mutant) + inhibitor + phosphate<br />
 
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**[[1z36]] – TvPNP + antibiotic<br />
 
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**[[3djf]] – SmPNP + inhibitor<br />
 
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**[[3e0q]] – SmPNP + pyrimidine derivative<br />
 
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**[[3fb1]] – SmPNP + ribose-1-phosphate <br />
 
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**[[5ko5]] - SmPNP + cytosine<br />
 
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**[[5ko6]] - SmPNP + cytosine + ribose-1-phosphate<br />
 
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**[[1a69]], [[1pr1]] – EcPNP + formycin <br />
 
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**[[1k9s]], [[3ut6]] – EcPNP + formycin derivative + phosphate<br />
 
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**[[2i4t]], [[2isc]] – TvPNP + inhibitor + phosphate<br />
 
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**[[2p4s]] – PNP + inhibitor + phosphate – ''Anopheles gambiae''<br />
 
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**[[3occ]] – YpPNP + inhibitor + phosphate<br />
 
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**[[3of3]] – VcPNP + inhibitor + phosphate<br />
 
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**[[3phc]] – PfPNP + inhibitor + phosphate<br />
 
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**[[4da6]], [[4da7]], [[4dar]] – BsPNP + drug<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry 1v2h)

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References

  1. ↑ Bzowska A, Kulikowska E, Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol Ther. 2000 Dec;88(3):349-425. PMID:11337031
  2. ↑ Markert ML. Purine nucleoside phosphorylase deficiency. Immunodefic Rev. 1991;3(1):45-81. PMID:1931007
  3. ↑ de Azevedo WF Jr, Canduri F, dos Santos DM, Pereira JH, Bertacine Dias MV, Silva RG, Mendes MA, Basso LA, Palma MS, Santos DS. Crystal structure of human PNP complexed with guanine. Biochem Biophys Res Commun. 2003 Dec 19;312(3):767-72. PMID:14680831 doi:10.1016/j.bbrc.2003.10.190

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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