2qis
From Proteopedia
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==Crystal structure of human farnesyl pyrophosphate synthase T210S mutant bound to risedronate== | ==Crystal structure of human farnesyl pyrophosphate synthase T210S mutant bound to risedronate== | ||
| - | <StructureSection load='2qis' size='340' side='right' caption='[[2qis]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='2qis' size='340' side='right'caption='[[2qis]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2qis]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2qis]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QIS FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qis OCA], [https://pdbe.org/2qis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qis RCSB], [https://www.ebi.ac.uk/pdbsum/2qis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qis ProSAT]</span></td></tr> |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Farnesyl diphosphate synthase|Farnesyl diphosphate synthase]] | + | *[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Dunford | + | [[Category: Dunford JE]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Evdokimov | + | [[Category: Evdokimov A]] |
| - | [[Category: Gileadi | + | [[Category: Gileadi O]] |
| - | [[Category: Hozjan | + | [[Category: Hozjan V]] |
| - | [[Category: Kavanagh | + | [[Category: Kavanagh KL]] |
| - | [[Category: Oppermann | + | [[Category: Oppermann U]] |
| - | + | [[Category: Sundstrom M]] | |
| - | [[Category: Sundstrom | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of human farnesyl pyrophosphate synthase T210S mutant bound to risedronate
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Dunford JE | Edwards A | Evdokimov A | Gileadi O | Hozjan V | Kavanagh KL | Oppermann U | Sundstrom M | Weigelt J | Von Delft F
