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2pr2

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Structure of Mycobacterium tuberculosis enoyl-ACP reductase with bound INH-NADP.

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Retrieved from "http://52.214.119.220/wiki/index.php/2pr2"

Categories: Large Structures | Mycobacterium tuberculosis H37Rv | Argyrou A | Blanchard JS | Vetting MW

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-[[Image:2pr2.jpg|left|200px]]
- {{Structure
+==Structure of Mycobacterium tuberculosis enoyl-ACP reductase with bound INH-NADP.==
-|PDB= 2pr2 |SIZE=350|CAPTION= <scene name='initialview01'>2pr2</scene>, resolution 2.500&Aring;
+<StructureSection load='2pr2' size='340' side='right'caption='[[2pr2]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=DG1:(4S)-ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE+DINUCLEOTIDE'>DG1</scene>
+<table><tr><td colspan='2'>[[2pr2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PR2 FirstGlance]. <br>
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-|GENE= inhA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DG1:(4S)-ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE+DINUCLEOTIDE'>DG1</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pr2 OCA], [https://pdbe.org/2pr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pr2 RCSB], [https://www.ebi.ac.uk/pdbsum/2pr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pr2 ProSAT]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pr2 OCA], [http://www.ebi.ac.uk/pdbsum/2pr2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pr2 RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/INHA_MYCTU INHA_MYCTU]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/2pr2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pr2 ConSurf].
+<div style="clear:both"></div>
-'''Structure of Mycobacterium tuberculosis enoyl-ACP reductase with bound INH-NADP.'''
+==See Also==
+*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-PR2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PR2 OCA].
+[[Category: Large Structures]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
-==Reference==
+[[Category: Argyrou A]]
-New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP., Argyrou A, Vetting MW, Blanchard JS, J Am Chem Soc. 2007 Aug 8;129(31):9582-3. Epub 2007 Jul 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17636923 17636923]
+[[Category: Blanchard JS]]
-[[Category: Enoyl-[acyl-carrier-protein] reductase (NADH)]]
+[[Category: Vetting MW]]
-[[Category: Mycobacterium tuberculosis]]
-[[Category: Single protein]]
-[[Category: Argyrou, A.]]
-[[Category: Blanchard, J S.]]
-[[Category: Vetting, M W.]]
-[[Category: drug target of isoniazid]]
-[[Category: oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:39:40 2008''

2pr2

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Current revision

Structure of Mycobacterium tuberculosis enoyl-ACP reductase with bound INH-NADP.

Structural highlights

Function

Evolutionary Conservation

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