2qzr
From Proteopedia
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==tRNA-Guanine Transglycosylase(TGT) in Complex with 6-amino-2-[(1-naphthylmethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one== | ==tRNA-Guanine Transglycosylase(TGT) in Complex with 6-amino-2-[(1-naphthylmethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one== | ||
| - | <StructureSection load='2qzr' size='340' side='right' caption='[[2qzr]], [[Resolution|resolution]] 1.95Å' scene=''> | + | <StructureSection load='2qzr' size='340' side='right'caption='[[2qzr]], [[Resolution|resolution]] 1.95Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2qzr]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2qzr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis Zymomonas mobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QZR FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=S79:6-AMINO-2-[(1-NAPHTHYLMETHYL)AMINO]-3,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>S79</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=S79:6-AMINO-2-[(1-NAPHTHYLMETHYL)AMINO]-3,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>S79</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qzr OCA], [https://pdbe.org/2qzr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qzr RCSB], [https://www.ebi.ac.uk/pdbsum/2qzr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qzr ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[TRNA-guanine transglycosylase|TRNA-guanine transglycosylase]] | + | *[[TRNA-guanine transglycosylase 3D structures|TRNA-guanine transglycosylase 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Diederich | + | [[Category: Large Structures]] |
| - | [[Category: Hoertner | + | [[Category: Zymomonas mobilis]] |
| - | [[Category: Kansy | + | [[Category: Diederich F]] |
| - | [[Category: Klebe | + | [[Category: Hoertner SR]] |
| - | [[Category: Kramer | + | [[Category: Kansy M]] |
| - | [[Category: Ritschel | + | [[Category: Klebe G]] |
| - | [[Category: Schweizer | + | [[Category: Kramer C]] |
| - | [[Category: Stengl | + | [[Category: Ritschel T]] |
| - | [[Category: Wagner | + | [[Category: Schweizer WB]] |
| - | + | [[Category: Stengl B]] | |
| - | + | [[Category: Wagner B]] | |
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Current revision
tRNA-Guanine Transglycosylase(TGT) in Complex with 6-amino-2-[(1-naphthylmethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
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Categories: Large Structures | Zymomonas mobilis | Diederich F | Hoertner SR | Kansy M | Klebe G | Kramer C | Ritschel T | Schweizer WB | Stengl B | Wagner B
