2r4r
From Proteopedia
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==Crystal structure of the human beta2 adrenoceptor== | ==Crystal structure of the human beta2 adrenoceptor== | ||
| - | <StructureSection load='2r4r' size='340' side='right' caption='[[2r4r]], [[Resolution|resolution]] 3.40Å' scene=''> | + | <StructureSection load='2r4r' size='340' side='right'caption='[[2r4r]], [[Resolution|resolution]] 3.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2r4r]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2r4r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The April 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adrenergic Receptors'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_4 10.2210/rcsb_pdb/mom_2008_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R4R FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4r OCA], [https://pdbe.org/2r4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r4r RCSB], [https://www.ebi.ac.uk/pdbsum/2r4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4r ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4r_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4r_consurf.spt"</scriptWhenChecked> | ||
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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==See Also== | ==See Also== | ||
*[[Adrenergic receptor|Adrenergic receptor]] | *[[Adrenergic receptor|Adrenergic receptor]] | ||
| - | *[[ | + | *[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]] |
*[[G protein-coupled receptor|G protein-coupled receptor]] | *[[G protein-coupled receptor|G protein-coupled receptor]] | ||
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | *[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | ||
| - | *[[Nobel Prizes for 3D Molecular Structure|Nobel Prizes for 3D Molecular Structure]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Adrenergic Receptors]] | [[Category: Adrenergic Receptors]] | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
| - | [[Category: Burghammer | + | [[Category: Burghammer M]] |
| - | [[Category: Choi | + | [[Category: Choi HJ]] |
| - | [[Category: Edwards | + | [[Category: Edwards PC]] |
| - | [[Category: Fischetti | + | [[Category: Fischetti RF]] |
| - | [[Category: Kobilka | + | [[Category: Kobilka BK]] |
| - | [[Category: Kobilka | + | [[Category: Kobilka TS]] |
| - | [[Category: Rasmussen | + | [[Category: Rasmussen SGF]] |
| - | [[Category: Ratnala | + | [[Category: Ratnala VR]] |
| - | [[Category: Rosenbaum | + | [[Category: Rosenbaum DM]] |
| - | [[Category: Sanishvili | + | [[Category: Sanishvili R]] |
| - | [[Category: Schertler | + | [[Category: Schertler GF]] |
| - | [[Category: Thian | + | [[Category: Thian FS]] |
| - | [[Category: Weis | + | [[Category: Weis WI]] |
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Current revision
Crystal structure of the human beta2 adrenoceptor
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