5zx1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of ENT domain from T. brucei== | |
| + | <StructureSection load='5zx1' size='340' side='right'caption='[[5zx1]], [[Resolution|resolution]] 2.31Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5zx1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZX1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zx1 OCA], [https://pdbe.org/5zx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zx1 RCSB], [https://www.ebi.ac.uk/pdbsum/5zx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zx1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q385P5_TRYB2 Q385P5_TRYB2] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Trypanosoma brucei (T. brucei) is a parasitic protozoan causing human sleeping sickness and related animal diseases. ENT (EMSY N-terminal) domain was first found in EMSY protein which has been proved to be involved in multiple biological processes such as DNA repair, tumorigenesis, and transcriptional regulation. So far, little is known about the function and structure of ENT domains from protozoan. Q385P5 from T. brucei, containing an ENT domain at its N-terminus, is a conserved protein in related kinetoplastid parasites. In this work, the crystal structure of ENT domain of Q385P5 (TbENT) was solved at a resolution of 2.3â¯A. TbENT adopts a club-like shape consisting of five helixes, which is similar to the structure of human EMSY ENT domain (HsENT). Interestingly, TbENT shows significantly different orientation on the fifth alpha-helix compared with HsENT. Meanwhile, human HP1 interacts with a conserved motif adjacent to EMSY ENT domain. However, this conserved binding motif is absent in Q385P5. These differences may imply the different protein interactions and roles of Q385P5 and its ENT domain in T. brucei. | ||
| - | + | Crystal structure of an ENT domain from Trypanosoma brucei.,Mi J, Yang X, Zhang J, Zhang X, Xu C, Liao S, Tu X Biochem Biophys Res Commun. 2018 Nov 2;505(3):755-760. doi: , 10.1016/j.bbrc.2018.09.167. Epub 2018 Oct 4. PMID:30293681<ref>PMID:30293681</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5zx1" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Trypanosoma brucei brucei TREU927]] | ||
| + | [[Category: Juan M]] | ||
| + | [[Category: Shanhui L]] | ||
| + | [[Category: Xiaoming T]] | ||
Current revision
Crystal structure of ENT domain from T. brucei
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