6hj7
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6hj7 is ON HOLD Authors: Nadezhdin, K.D., Mineev, K.S., Goncharuk, S.A., Arseniev, A.S. Description: The NMR structure of NRADD death domain [[Cate...) |
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The NMR structure of NRADD death domain== |
| + | <StructureSection load='6hj7' size='340' side='right'caption='[[6hj7]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6hj7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HJ7 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hj7 OCA], [https://pdbe.org/6hj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hj7 RCSB], [https://www.ebi.ac.uk/pdbsum/6hj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hj7 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NRADD_MOUSE NRADD_MOUSE] Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR.<ref>PMID:12728256</ref> <ref>PMID:12843241</ref> <ref>PMID:19407813</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Structural study of any single-pass membrane protein is both an important and challenging task. In this report, we present the structure of a neurotrophin receptor-alike death-domain protein, NRADD. The structure and dynamics of the protein was investigated by conventional nuclear magnetic resonance techniques in the solution of phospholipid bicelles. The receptor contains two folded regions - alpha-helical transmembrane domain and globular C-terminal death domain with more than 50% of the rest of backbone being disordered. This is the first structure of a full-length single-pass membrane receptor-alike protein solved by the single method. This article is protected by copyright. All rights reserved. | ||
| - | + | NMR structure of a full-length single-pass membrane protein NRADD.,Nadezhdin KD, Goncharuk SA, Arseniev AS, Mineev KS Proteins. 2019 Apr 29. doi: 10.1002/prot.25703. PMID:31033000<ref>PMID:31033000</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6hj7" style="background-color:#fffaf0;"></div> |
| - | [[Category: Arseniev | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Arseniev AS]] | ||
| + | [[Category: Goncharuk SA]] | ||
| + | [[Category: Mineev KS]] | ||
| + | [[Category: Nadezhdin KD]] | ||
Current revision
The NMR structure of NRADD death domain
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