4ym9

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==Crystal structure of Porcine Pancreatic Elastase (PPE) in complex with the novel inhibitor JM102==
==Crystal structure of Porcine Pancreatic Elastase (PPE) in complex with the novel inhibitor JM102==
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<StructureSection load='4ym9' size='340' side='right' caption='[[4ym9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4ym9' size='340' side='right'caption='[[4ym9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ym9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YM9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ym9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YM9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4E4:2-ETHYL-2-(HYDROXYMETHYL)-N-(6-METHYLPYRIDIN-3-YL)BUTANAMIDE'>4E4</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4E4:2-ETHYL-2-(HYDROXYMETHYL)-N-(6-METHYLPYRIDIN-3-YL)BUTANAMIDE'>4E4</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ym9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ym9 OCA], [http://pdbe.org/4ym9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ym9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ym9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ym9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ym9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ym9 OCA], [https://pdbe.org/4ym9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ym9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ym9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ym9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG]] Acts upon elastin.
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[https://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG] Acts upon elastin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4ym9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4ym9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Elastase 3D structures|Elastase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pancreatic elastase]]
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[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Archer, M]]
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[[Category: Archer M]]
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[[Category: Brito, J A]]
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[[Category: Brito JA]]
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[[Category: Hofbauer, S]]
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[[Category: Hofbauer S]]
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[[Category: Moreira, R]]
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[[Category: Moreira R]]
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[[Category: Mulchande, J]]
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[[Category: Mulchande J]]
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[[Category: Nogly, P]]
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[[Category: Nogly P]]
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[[Category: Pessanha, M]]
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[[Category: Pessanha M]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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[[Category: Porcine pancreatic elastase]]
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Current revision

Crystal structure of Porcine Pancreatic Elastase (PPE) in complex with the novel inhibitor JM102

PDB ID 4ym9

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