2vb6

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==Myosin VI (MD-insert2-CaM, Delta Insert1) Post-rigor state (crystal form 2)==
==Myosin VI (MD-insert2-CaM, Delta Insert1) Post-rigor state (crystal form 2)==
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<StructureSection load='2vb6' size='340' side='right' caption='[[2vb6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='2vb6' size='340' side='right'caption='[[2vb6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vb6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick] and [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VB6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vb6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VB6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bkh|2bkh]], [[2v26|2v26]], [[2bki|2bki]], [[2vas|2vas]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb6 OCA], [http://pdbe.org/2vb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vb6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb6 OCA], [https://pdbe.org/2vb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vb6 RCSB], [https://www.ebi.ac.uk/pdbsum/2vb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref> [[http://www.uniprot.org/uniprot/CALM_CHICK CALM_CHICK]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
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[https://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Calmodulin|Calmodulin]]
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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*[[Myosin|Myosin]]
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*[[Myosin 3D Structures|Myosin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chick]]
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[[Category: Gallus gallus]]
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[[Category: Pig]]
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[[Category: Large Structures]]
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[[Category: Cicolari, J]]
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[[Category: Sus scrofa]]
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[[Category: Houdusse, A]]
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[[Category: Cicolari J]]
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[[Category: Li, A]]
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[[Category: Houdusse A]]
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[[Category: Liu, X]]
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[[Category: Li A]]
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[[Category: Llinas, P]]
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[[Category: Liu X]]
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[[Category: Menetrey, J]]
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[[Category: Llinas P]]
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[[Category: Squires, G]]
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[[Category: Menetrey J]]
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[[Category: Sweeney, H L]]
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[[Category: Squires G]]
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[[Category: Calmodulin]]
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[[Category: Sweeney HL]]
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[[Category: Cam]]
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[[Category: Mg adp befx]]
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[[Category: Molecular motor]]
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[[Category: Motor protein]]
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[[Category: Myosin vi]]
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[[Category: Post-rigor state]]
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Current revision

Myosin VI (MD-insert2-CaM, Delta Insert1) Post-rigor state (crystal form 2)

PDB ID 2vb6

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