2pxh

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[[Image:2pxh.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of a bipyridylalanyl-tRNA synthetase==
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|PDB= 2pxh |SIZE=350|CAPTION= <scene name='initialview01'>2pxh</scene>, resolution 1.970&Aring;
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<StructureSection load='2pxh' size='340' side='right'caption='[[2pxh]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Bp5+Binding+Site+For+Residue+A+308'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=BP5:3-(2,2&#39;-BIPYRIDIN-5-YL)-L-ALANINE'>BP5</scene>
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<table><tr><td colspan='2'>[[2pxh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PXH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PXH FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
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|GENE= tyrosyl-tRNA synthetase ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BP5:3-(2,2-BIPYRIDIN-5-YL)-L-ALANINE'>BP5</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pxh OCA], [https://pdbe.org/2pxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pxh RCSB], [https://www.ebi.ac.uk/pdbsum/2pxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pxh ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1j1u|1J1U]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pxh OCA], [http://www.ebi.ac.uk/pdbsum/2pxh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pxh RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/SYY_METJA SYY_METJA] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).<ref>PMID:10585437</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/px/2pxh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pxh ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of a bipyridylalanyl-tRNA synthetase'''
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2PXH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PXH OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Large Structures]]
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A genetically encoded bidentate, metal-binding amino acid., Xie J, Liu W, Schultz PG, Angew Chem Int Ed Engl. 2007;46(48):9239-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17893898 17893898]
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[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Single protein]]
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[[Category: Liu W]]
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[[Category: Tyrosine--tRNA ligase]]
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[[Category: Schultz PG]]
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[[Category: Liu, W.]]
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[[Category: Xie J]]
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[[Category: Schultz, P G.]]
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[[Category: Xie, J.]]
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[[Category: bipyridylalanine]]
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[[Category: ligase]]
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[[Category: metal chelator]]
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[[Category: unnatural amino acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:42:05 2008''
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Current revision

Crystal structure of a bipyridylalanyl-tRNA synthetase

PDB ID 2pxh

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