1upr
From Proteopedia
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==Crystal structure of the PEPP1 pleckstrin homology domain in complex with Inositol 1,3,4,5-tetrakisphosphate== | ==Crystal structure of the PEPP1 pleckstrin homology domain in complex with Inositol 1,3,4,5-tetrakisphosphate== | ||
| - | <StructureSection load='1upr' size='340' side='right' caption='[[1upr]], [[Resolution|resolution]] 2.27Å' scene=''> | + | <StructureSection load='1upr' size='340' side='right'caption='[[1upr]], [[Resolution|resolution]] 2.27Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1upr]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1upr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UPR FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4IP:INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE'>4IP</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1upr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1upr OCA], [https://pdbe.org/1upr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1upr RCSB], [https://www.ebi.ac.uk/pdbsum/1upr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1upr ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PKHA4_HUMAN PKHA4_HUMAN] Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides.<ref>PMID:11001876</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Alessi | + | [[Category: Alessi DR]] |
| - | [[Category: Deak | + | [[Category: Deak M]] |
| - | [[Category: Komander | + | [[Category: Komander D]] |
| - | [[Category: Milburn | + | [[Category: Milburn CC]] |
| - | [[Category: | + | [[Category: Van Aalten DMF]] |
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Current revision
Crystal structure of the PEPP1 pleckstrin homology domain in complex with Inositol 1,3,4,5-tetrakisphosphate
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