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2rr7

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==Microtubule Binding Domain of DYNEIN-C==
==Microtubule Binding Domain of DYNEIN-C==
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<StructureSection load='2rr7' size='340' side='right' caption='[[2rr7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2rr7' size='340' side='right'caption='[[2rr7]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2rr7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlre Chlre]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RR7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2rr7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RR7 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DHC9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3055 CHLRE])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rr7 OCA], [http://pdbe.org/2rr7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rr7 RCSB], [http://www.ebi.ac.uk/pdbsum/2rr7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rr7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rr7 OCA], [https://pdbe.org/2rr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rr7 RCSB], [https://www.ebi.ac.uk/pdbsum/2rr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rr7 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q4AC22_CHLRE Q4AC22_CHLRE]
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Flagellar dyneins are essential microtubule motors in eukaryotes, as they drive the beating motions of cilia and flagella. Unlike myosin and kinesin motors, the track binding mechanism of dyneins and the regulation between the strong and weak binding states remain obscure. Here we report the solution structure of the microtubule-binding domain of flagellar dynein-c/DHC9 (dynein-c MTBD). The structure reveals a similar overall helix-rich fold to that of the MTBD of cytoplasmic dynein (cytoplasmic MTBD), but dynein-c MTBD has an additional flap, consisting of an antiparallel b sheet. The flap is positively charged and highly flexible. Despite the structural similarity to cytoplasmic MTBD, dynein-c MTBD shows only a small change in the microtubule- binding affinity depending on the registry change of coiled coil-sliding, whereby lacks the apparent strong binding state. The surface charge distribution of dynein-c MTBD also differs from that of cytoplasmic MTBD, which suggests a difference in the microtubule-binding mechanism.
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Structure of the microtubule-binding domain of flagellar dynein.,Kato YS, Yagi T, Harris SA, Ohki SY, Yura K, Shimizu Y, Honda S, Kamiya R, Burgess SA, Tanokura M Structure. 2014 Nov 4;22(11):1628-38. PMID:25450768<ref>PMID:25450768</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2rr7" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Dynein|Dynein]]
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*[[Dynein 3D structures|Dynein 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chlre]]
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[[Category: Chlamydomonas reinhardtii]]
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[[Category: Burgess, S]]
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[[Category: Large Structures]]
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[[Category: Honda, S]]
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[[Category: Burgess S]]
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[[Category: Kamiya, R]]
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[[Category: Honda S]]
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[[Category: Kato, Y]]
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[[Category: Kamiya R]]
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[[Category: Ohki, S]]
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[[Category: Kato Y]]
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[[Category: Tanokura, M]]
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[[Category: Ohki S]]
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[[Category: Yagi, T]]
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[[Category: Tanokura M]]
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[[Category: Antiparallel coiled coil]]
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[[Category: Yagi T]]
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[[Category: Dsh]]
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[[Category: Dynein]]
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[[Category: Microtubule-binding]]
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[[Category: Motor protein]]
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[[Category: Mtbd]]
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[[Category: Stalk head]]
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Current revision

Microtubule Binding Domain of DYNEIN-C

PDB ID 2rr7

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