2rr6

<StructureSection load='2rr6' size='340' side='right' caption='[[2rr6]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[2rr6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RR6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RR6 FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ell|2ell]]</td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ANP32B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rr6 OCA], [http://pdbe.org/2rr6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rr6 RCSB], [http://www.ebi.ac.uk/pdbsum/2rr6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rr6 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/AN32B_HUMAN AN32B_HUMAN]] Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.<ref>PMID:20538007</ref>

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

Eukaryotic gene expression is regulated by histone deposition onto and eviction from nucleosomes, which are mediated by several chromatin-modulating factors. Among them, histone chaperones are key factors that facilitate nucleosome assembly. Acidic nuclear phosphoprotein 32B (ANP32B) belongs to the ANP32 family, which shares N-terminal leucine-rich repeats (LRRs) and a C-terminal variable anionic region. The C-terminal region functions as an inhibitor of histone acetylation, but the functional roles of the LRR domain in chromatin regulation have remained elusive. Here, we report that the LRR domain of ANP32B possesses histone chaperone activity and forms a curved structure with a parallel beta-sheet on the concave side and mostly helical elements on the convex side. Our analyses revealed that the interaction of ANP32B with the core histones H3-H4 occurs on its concave side, and both the acidic and hydrophobic residues that compose the concave surface are critical for histone binding. These results provide a structural framework for understanding the functional mechanisms of acidic histone chaperones.

Solution structure of histone chaperone ANP32B: interaction with core histones H3-H4 through its acidic concave domain.,Tochio N, Umehara T, Munemasa Y, Suzuki T, Sato S, Tsuda K, Koshiba S, Kigawa T, Nagai R, Yokoyama S J Mol Biol. 2010 Aug 6;401(1):97-114. Epub 2010 Jun 9. PMID:20538007<ref>PMID:20538007</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2rr6" style="background-color:#fffaf0;"></div>

[[Category: Human]]

[[Category: Harada, T]]

[[Category: Kigawa, T]]

[[Category: Koshiba, S]]

[[Category: Tanaka, A]]

[[Category: Tochio, N]]

[[Category: Tsuda, K]]

[[Category: Umehara, T]]

[[Category: Watanabe, S]]

[[Category: Yokoyama, S]]

[[Category: Silver-stainable protein ssp29]]