SAICAR synthetase

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== Structural highlights ==
== Structural highlights ==
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SAI structure shows <scene name='74/749400/Cv/2'>two domains</scene>. The <scene name='74/749400/Cv/9'>active site is located in a hydrophilic tunnel</scene> between the 2 domains and contains <scene name='74/749400/Cv/4'>ADP</scene>, <scene name='74/749400/Cv/6'>aspartic acid</scene> and <scene name='74/749400/Cv/7'>aminoimidazole-ribonucleotide (AIR)</scene><ref>PMID:24598753</ref>. Residues are colored according to {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}. Water molecules shown as red spheres.
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SAI structure shows <scene name='74/749400/Cv/10'>two domains</scene>. The <scene name='74/749400/Cv/11'>active site is located in a hydrophilic tunnel</scene> between the 2 domains and contains <scene name='74/749400/Cv/12'>ADP</scene>, <scene name='74/749400/Cv/13'>aspartic acid</scene> and <scene name='74/749400/Cv/14'>aminoimidazole-ribonucleotide (AIR)</scene><ref>PMID:24598753</ref>. Residues are colored according to {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}. Water molecules are shown as red spheres.
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*<scene name='74/749400/Cv/3'>Surface representation of hydrophilic tunnel</scene>.
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*<scene name='74/749400/Cv/15'>Surface representation of hydrophilic tunnel</scene>.
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*<scene name='74/749400/Cv/5'>Mg coordination site</scene>.
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*<scene name='74/749400/Cv/16'>Mg coordination site</scene>.
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*<scene name='74/749400/Cv/8'>Whole active site</scene>.
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*<scene name='74/749400/Cv/17'>Whole active site</scene>.
</StructureSection>
</StructureSection>
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**[[1a48]] – ySAI - yeast<br />
**[[1a48]] – ySAI - yeast<br />
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**[[3r9r]] – SAI – ''Mycobacterium abscessus'' <br />
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**[[3r9r]], [[6yvq]] – MaSAI – ''Mycobacterium abscessus'' <br />
**[[3kre]] – SAI – ''Ehrlichia chaffeensis'' <br />
**[[3kre]] – SAI – ''Ehrlichia chaffeensis'' <br />
**[[1kut]] – SAI – ''Thermotoga maritima''<br />
**[[1kut]] – SAI – ''Thermotoga maritima''<br />
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**[[2gqr]] – EcSAI + ADP – ''Escherichia coli''<br />
**[[2gqr]] – EcSAI + ADP – ''Escherichia coli''<br />
**[[2gqs]] – EcSAI + ADP + AICAR <br />
**[[2gqs]] – EcSAI + ADP + AICAR <br />
 +
**[[6yy6]], [[6yy7]], [[6yy8]], [[6yy9]], [[6yya]], [[6yyb]], [[6yyc]], [[6yyd]], [[6z0q]], [[6z0r]] – MaSAI + inhibitor<br />
 +
**[[6yx3]] – MaSAI + ATP <br />
*SAICAR synthetase type-1
*SAICAR synthetase type-1

Current revision

SAICAR synthetase complex with aminoimidazole-ribonucleotide, ADP, TRIS, aspartate, acetate, Mg+2 and Cl- ions (PDB code 4fe2)

Drag the structure with the mouse to rotate

3D structures of SAICAR synthetase

Updated on 09-March-2022

References

  1. ↑ Manjunath K, Jeyakanthan J, Sekar K. Catalytic pathway, substrate binding and stability in SAICAR synthetase: A structure and molecular dynamics study. J Struct Biol. 2015 Jul;191(1):22-31. doi: 10.1016/j.jsb.2015.06.006. Epub 2015, Jun 10. PMID:26072057 doi:http://dx.doi.org/10.1016/j.jsb.2015.06.006
  2. ↑ Wolf NM, Abad-Zapatero C, Johnson ME, Fung LW. Structures of SAICAR synthetase (PurC) from Streptococcus pneumoniae with ADP, Mg(2+), AIR and Asp. Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):841-50. doi:, 10.1107/S139900471303366X. Epub 2014 Feb 22. PMID:24598753 doi:http://dx.doi.org/10.1107/S139900471303366X

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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