SAM decarboxylase

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==Structural insight ==
==Structural insight ==
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The biological assembly of S-adenosylmethionine decarboxylase is <scene name='49/493297/Cv/2'>tetramer</scene>, containing 2 α and 2 β chains. <scene name='49/493297/Cv/4'>AMD active site contains residues from all protomers</scene>. The cleavage of the precursor molecule occurs at residue <scene name='49/493297/Cv/5'>serine 63 which becomes a pyruvolyl group</scene><ref>PMID:20124698</ref>. Water molecules shown as red spheres.
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The biological assembly of S-adenosylmethionine decarboxylase is <scene name='49/493297/Cv/6'>tetramer</scene>, containing 2 α and 2 β chains. <scene name='49/493297/Cv/7'>AMD active site contains residues from all protomers</scene>. The cleavage of the precursor molecule occurs at residue <scene name='49/493297/Cv/8'>serine 63 which becomes a pyruvolyl group</scene><ref>PMID:20124698</ref>. Water molecules are shown as red spheres.
</StructureSection>
</StructureSection>
==3D structures of S-adenosylmethionine decarboxylase==
==3D structures of S-adenosylmethionine decarboxylase==
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*S-adenosylmethionine decarboxylase
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*S-adenosylmethionine decarboxylase binary complexes
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**[[3iwb]] - TmAMD (mutant) + pyruvate - ''Thermotoga maritima''<br />
 
**[[1jen]], [[3ep9]] – hAMD + pyruvate – human<br />
**[[1jen]], [[3ep9]] – hAMD + pyruvate – human<br />
**[[3ep3]], [[3ep4]], [[3ep5]] - hAMD (mutant) + pyruvate<br />
**[[3ep3]], [[3ep4]], [[3ep5]] - hAMD (mutant) + pyruvate<br />
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**[[1mhm]] - AMD + pyruvate – potato
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**[[1jl0]] - hAMD (mutant) + putrescine <br />
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**[[1mhm]] - AMD + pyruvate – potato<br />
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**[[3iwb]] - TmAMD (mutant) + pyruvate - ''Thermotoga maritima''<br />
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*S-adenosylmethionine decarboxylase binary complex
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*S-adenosylmethionine decarboxylase ternary complex
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**[[1jl0]] - hAMD (mutant) + putrescine <br />
 
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**[[3iwc]] - TmAMD + AdoMet + pyruvate<br />
 
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**[[3iwd]] - TmAMD + adenosine derivative + pyruvate<br />
 
**[[3ep6]], [[3ep7]], [[3ep8]] - hAMD (mutant) + AdoMet + pyruvate<br />
**[[3ep6]], [[3ep7]], [[3ep8]] - hAMD (mutant) + AdoMet + pyruvate<br />
**[[3epa]], [[3epb]] - hAMD (mutant) + putrescine + pyruvate<br />
**[[3epa]], [[3epb]] - hAMD (mutant) + putrescine + pyruvate<br />
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**[[3iwc]] - TmAMD + AdoMet + pyruvate<br />
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**[[3iwd]] - TmAMD + adenosine derivative + pyruvate<br />
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*S-adenosylmethionine decarboxylase ternary complex
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*S-adenosylmethionine decarboxylase quaternary complex
**[[1i72]], [[1i79]], [[3dz2]], [[3dz4]], [[3dz5]], [[3dz6]], [[3dz7]], [[3h0v]], [[3h0w]] - hAMD + adenosine derivative + putrescine + pyruvate<br />
**[[1i72]], [[1i79]], [[3dz2]], [[3dz4]], [[3dz5]], [[3dz6]], [[3dz7]], [[3h0v]], [[3h0w]] - hAMD + adenosine derivative + putrescine + pyruvate<br />
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*S-adenosylmethionine decarboxylase precursor
*S-adenosylmethionine decarboxylase precursor
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**[[1tlu]], [[1vr7]] - TmAMD <br />
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**[[1msv]] - hAMDP (mutant) + putrescine<br />
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**[[1tmi]] - TmAMD (mutant)<br />
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**[[1tlu]], [[1vr7]] - TmAMDP <br />
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**[[2iii]] – AMD – ''Aquifex aeolicus''<br />
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**[[1tmi]] - TmAMDP (mutant)<br />
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**[[1msv]] - hAMD (mutant) + putrescine<br />
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**[[2iii]] – AMDP – ''Aquifex aeolicus''<br />
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**[[5tvo]] - TbAMD + pyruvate<br />
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**[[5tvo]] - TbAMDP + pyruvate<br />
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}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

S-adenosylmethionine decarboxylase with cofactor pyruvate complex with AdoMet 3iwc

Drag the structure with the mouse to rotate

3D structures of S-adenosylmethionine decarboxylase

Updated on 13-March-2022

References

  1. ↑ Mad Arif SA, Taylor MA, George LA, Butler AR, Burch LR, Davies HV, Stark MJ, Kumar A. Characterisation of the S-adenosylmethionine decarboxylase (SAMDC) gene of potato. Plant Mol Biol. 1994 Oct;26(1):327-38. PMID:7948879
  2. ↑ Weisel FC, Kloepping C, Pichl A, Sydykov A, Kojonazarov B, Wilhelm J, Roth M, Ridge KM, Igarashi K, Nishimura K, Maison W, Wackendorff C, Klepetko W, Jaksch P, Ghofrani HA, Grimminger F, Seeger W, Schermuly RT, Weissmann N, Kwapiszewska G. Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling. Circulation. 2014 Apr 8;129(14):1510-23. doi: 10.1161/CIRCULATIONAHA.113.006402. , Epub 2014 Jan 27. PMID:24470481 doi:http://dx.doi.org/10.1161/CIRCULATIONAHA.113.006402
  3. ↑ Bale S, Baba K, McCloskey DE, Pegg AE, Ealick SE. Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity. Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):181-9. Epub 2010, Jan 22. PMID:20124698 doi:10.1107/S090744490904877X

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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