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2q5f

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[[Image:2q5f.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of LMNADK1 from Listeria monocytogenes==
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|PDB= 2q5f |SIZE=350|CAPTION= <scene name='initialview01'>2q5f</scene>, resolution 1.90&Aring;
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<StructureSection load='2q5f' size='340' side='right'caption='[[2q5f]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=DTA:(2S,3S,4R,5R,2&#39;S,3&#39;S,4&#39;R,5&#39;R)-2,2&#39;-[DITHIOBIS(METHYLENE)]BIS[5-(6-AMINO-9H-PURIN-9-YL)TETRAHYDROFURAN-3,4-DIOL]'>DTA</scene>
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<table><tr><td colspan='2'>[[2q5f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q5F FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_kinase NAD(+) kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.23 2.7.1.23] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE= ppnK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1639 Listeria monocytogenes])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTA:(2S,3S,4R,5R,2S,3S,4R,5R)-2,2-[DITHIOBIS(METHYLENE)]BIS[5-(6-AMINO-9H-PURIN-9-YL)TETRAHYDROFURAN-3,4-DIOL]'>DTA</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q5f OCA], [https://pdbe.org/2q5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q5f RCSB], [https://www.ebi.ac.uk/pdbsum/2q5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q5f ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2i2c|2I2C]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q5f OCA], [http://www.ebi.ac.uk/pdbsum/2q5f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2q5f RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/NADK1_LISMO NADK1_LISMO] Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.[HAMAP-Rule:MF_00361]<ref>PMID:17686780</ref> <ref>PMID:22608967</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q5/2q5f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q5f ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of LMNADK1 from Listeria monocytogenes'''
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==See Also==
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*[[NAD kinase|NAD kinase]]
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== References ==
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==About this Structure==
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<references/>
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2Q5F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q5F OCA].
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__TOC__
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[[Category: Listeria monocytogenes]]
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</StructureSection>
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[[Category: NAD(+) kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Listeria monocytogenes EGD-e]]
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[[Category: Arold, S.]]
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[[Category: Arold S]]
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[[Category: Assairi, L.]]
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[[Category: Assairi L]]
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[[Category: Labesse, G.]]
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[[Category: Labesse G]]
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[[Category: Pochet, S.]]
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[[Category: Pochet S]]
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[[Category: Poncet-Montange, G.]]
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[[Category: Poncet-Montange G]]
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[[Category: mutant]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:45:02 2008''
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Current revision

Crystal structure of LMNADK1 from Listeria monocytogenes

PDB ID 2q5f

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