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2vqz

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==Structure of the cap-binding domain of influenza virus polymerase subunit PB2 with bound m7GTP==
==Structure of the cap-binding domain of influenza virus polymerase subunit PB2 with bound m7GTP==
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<StructureSection load='2vqz' size='340' side='right' caption='[[2vqz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='2vqz' size='340' side='right'caption='[[2vqz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vqz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VQZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vqz]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VQZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jdq|2jdq]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vqz OCA], [https://pdbe.org/2vqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vqz RCSB], [https://www.ebi.ac.uk/pdbsum/2vqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vqz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vqz OCA], [http://pdbe.org/2vqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vqz RCSB], [http://www.ebi.ac.uk/pdbsum/2vqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vqz ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PB2_I75A3 PB2_I75A3]] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).
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[https://www.uniprot.org/uniprot/PB2_I75A3 PB2_I75A3] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[RNA polymerase|RNA polymerase]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Coloma, R]]
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[[Category: Influenza A virus]]
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[[Category: Crepin, T]]
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[[Category: Large Structures]]
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[[Category: Cusack, S]]
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[[Category: Coloma R]]
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[[Category: Guilligay, D]]
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[[Category: Crepin T]]
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[[Category: Hart, D J]]
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[[Category: Cusack S]]
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[[Category: Lewis, J]]
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[[Category: Guilligay D]]
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[[Category: Ortin, J]]
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[[Category: Hart DJ]]
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[[Category: Resa-Infante, P]]
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[[Category: Lewis J]]
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[[Category: Ruigrok, R W.H]]
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[[Category: Ortin J]]
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[[Category: Sehr, P]]
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[[Category: Resa-Infante P]]
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[[Category: Tarendeau, F]]
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[[Category: Ruigrok RWH]]
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[[Category: Cap-binding domain]]
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[[Category: Sehr P]]
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[[Category: Influenza virus]]
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[[Category: Tarendeau F]]
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[[Category: Pb2 subunit]]
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[[Category: Rna-dependent rna polymerase]]
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[[Category: Transcription]]
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Current revision

Structure of the cap-binding domain of influenza virus polymerase subunit PB2 with bound m7GTP

PDB ID 2vqz

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