Symporter

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<StructureSection load='' size='350' side='right' caption='Dipeptide:H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code [[4d2c]])' scene='70/705726/Initial/2'>
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<StructureSection load='' size='350' side='right' caption='Dipeptide: H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code [[4d2c]])' scene='70/705726/Initial/2'>
== Function ==
== Function ==
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Symporter (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction<ref>PMID:12588808</ref>.
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'''Symporter''' (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction<ref>PMID:12588808</ref>.
== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==
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Dipeptide:<scene name='70/705726/Cv/4'>H symporter binds the dipeptide</scene> between its N- and C-terminal bundles<ref>PMID:24916388</ref>.
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Dipeptide: <scene name='70/705726/Cv/5'>H symporter binds the dipeptide</scene> between its N- and C-terminal bundles<ref>PMID:24916388</ref>.
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</StructureSection>
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== 3D Structures of symporter ==
== 3D Structures of symporter ==
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[[Symporter 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*D-xylose/H+ symporter
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**[[4ja4]], [[4qiq]] – EcSymp – ''Escherichia coli''<BR />
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**[[4ja3]] – EcSymp (mutant) <BR />
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**[[4gby]] – EcSymp + xylose <BR />
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**[[4gbz]], [[4gc0]] – EcSymp + glucose derivative<BR />
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*Di-or tripeptide/H+ symporter
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**[[4ja4]], [[4xni]], [[4xnj]], [[4d2b]], [[4aps]], [[5d6k]], [[5mmt]], [[5d6k]], [[5oxo]], [[5oxp]], [[5oxq]], [[6eia]], [[6fmr]], [[6fmy]] – StSymp – ''Streptococcus thermophilus''<BR />
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**[[4d2d]], [[6ghj]] – StSymp + tripeptide<BR />
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**[[4d2c]], [[5d58]], [[5d59]], [[5oxk]], [[5oxl]], [[5oxm]], [[5oxn]] – StSymp + dipeptide<BR />
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*Oligopeptide/H+ symporter
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**[[4lep]], [[4tph]] – SoSymp – ''Shewanella oneidensis''<BR />
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**[[2xut]] – SoSymp (mutant) <BR />
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**[[4tpg]], [[4tpj]] – SoSymp + tripeptide<BR />
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*Bile acid/Na+ symporter
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**[[4n7w]] – YfSymp – ''Yersinia frederiksenii''<BR />
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**[[4n7x]] – YfSymp (mutant) <BR />
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**[[3zuy]] – Symp - ''Neisseria meningitidis''<BR />
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**[[3zux]] – Symp (mutant) <BR />
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*L-fucose/H+ symporter
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**[[3o7q]] – EcSymp <BR />
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**[[3o7p]] – EcSymp (mutant)<BR />
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*Lactose/H+ symporter
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**[[1pv6]] – EcSymp (mutant)<BR />
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**[[1pv7]], [[4oaa]] – EcSymp (mutant) + thiodigalactoside<BR />
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*Glucose/Na+ symporter
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**[[2xq2]] – VpSymp (mutant) – ''Vibrio parahaemolyticus''<BR />
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**[[3dh4]] – VpSymp + galactose <BR />
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**[[4m64]] – Symp (mutant) - ''Salmonella typhimurium''<BR />
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*Citrate/Na+ symporter
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**[[5a1s]] – Symp + citrate + Na – ''Salmonella enterica''<BR />
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**[[5x9r]], [[5xas]], [[5xat]] – KpSymp + citrate + Na – ''Klebsiella pneumoniae''<BR />
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**[[4bpq]], [[5xar]] – KpSymp <BR />
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*Neurotransmitter/leucine symporter LeuT
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**[[5jaf]], [[5jae]] – AaSymp - ''Aquifex aeolicus''<BR />
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**[[5jag]] – AaSymp (mutant) <BR />
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**[[3gjd]] – AaSymp + Na <BR />
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**[[3f48]] – AaSymp + alaine + Na<BR />
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**[[3tu0]] – AaSymp (mutant) + alanine + Na <BR />
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**[[3f4j]] – AaSymp + glycine + Na<BR />
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**[[2a65]], [[3f3e]], [[3usg]], [[3usi]], [[3usj]], [[3usk]] – AaSymp + leucine + Na<BR />
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**[[3mpn]], [[3mpq]], [[3gjc]], [[4hmk]], [[4hod]], [[4fxz]] – AaSymp (mutant) + leucine + Na<BR />
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**[[3f3a]] – AaSymp + tryptophan + Na <BR />
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**[[3qs4]], [[3qs5]], [[3qs6]] – AaSymp (mutant) + tryptophan + Na <BR />
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**[[3f3c]] – AaSymp + phenylalanine + Na <BR />
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**[[3f3d]], [[3f4i]], [[3usl]], [[3usm]], [[3uso]] – AaSymp + methionine derivative + Na <BR />
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**[[4fy0]] – AaSymp (mutant) + methionine + Na <BR />
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**[[2qei]] – AaSymp + alaine + clomipramine + Na<BR />
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**[[3gwu]] – AaSymp + sertraline + Na<BR />
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**[[3gwv]], [[3gww]], [[2qb4]], [[2q6h]], [[2q72]], [[2qju]] – AaSymp + drug + Na<BR />
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**[[4mm4]] – AaSymp (mutant) + drug + Na<BR />
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**[[3usp]] – AaSymp + glucoside derivative + Na <BR />
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**[[3tt1]], [[3tt3]] – AaSymp (mutant) + antibody + Na <BR />
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*Divalent ion/Na+ symporter
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**[[5ul7]], [[5ul9]], [[5uld]], [[5ule]], [[4f35]] – Symp + Na – ''Vibrio cholerae''<BR />
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*Purine/H+ symporter
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**[[5i6c]] – Symp + xanthine – ''Aspergillus nidulans''<BR />
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*Glutamate/H+ symporter
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**[[5dwy]], [[4ky0]] – TkSymp – ''Thermococcus kodakarensis''<BR />
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**[[5e9s]] – TkSymp + aspartate<BR />
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**[[4oyf]] – PhSymp - ''Pyrococcus horikishii'' <BR />
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**[[2nwl]] – PhSymp (mutant) + aspartate<BR />
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Dipeptide: H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code 4d2c)

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References

  1. ↑ Dohan O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginter CS, Carrasco N. The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. Endocr Rev. 2003 Feb;24(1):48-77. PMID:12588808 doi:http://dx.doi.org/10.1210/er.2001-0029
  2. ↑ Pohlenz J, Refetoff S. Mutations in the sodium/iodide symporter (NIS) gene as a cause for iodide transport defects and congenital hypothyroidism. Biochimie. 1999 May;81(5):469-76. PMID:10403177
  3. ↑ Lyons JA, Parker JL, Solcan N, Brinth A, Li D, Shah ST, Caffrey M, Newstead S. Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters. EMBO Rep. 2014 Jun 10. pii: e201338403. PMID:24916388 doi:http://dx.doi.org/10.15252/embr.201338403

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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