TIR domain-containing adapter protein
From Proteopedia
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<StructureSection load='3ub2' size='340' side='right' caption='MAL adaptor protein TIR domain complex with dithiothreitol (PDB code [[3ub2]])' scene=''> | <StructureSection load='3ub2' size='340' side='right' caption='MAL adaptor protein TIR domain complex with dithiothreitol (PDB code [[3ub2]])' scene=''> | ||
| - | '''TIR domain-containing | + | '''TIR domain-containing adapter protein''' or '''Toll/Interleukin-1 receptor domain-containing adapter protein''' (TIRAP) is one of 5 proteins involved in the Toll interleukin 1 receptor signaling pathway of the immune system. The 5 adaptor proteins are: '''MyD88, MAL, TRIF, TRAM and SARM'''. The TIR domain is found in Toll-like receptors and in adaptor proteins. The domain containing 135 to 160 amino acids, consists of 3 boxes of conserved residues. The TIR domain is involved in the interaction between Toll-like receptors and the adaptor protein<ref>PMID:17457343</ref>. TIRAP activates NF-kB, MAPK1, MAPK3 and JNK which results in the inflammatory response. |
</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of TIR domain-containing | + | == 3D Structures of TIR domain-containing adapter protein == |
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *MAL | + | *TIRAP or Toll/interleukin-1 receptor domain-containing adapter protein or MAL |
| - | **[[2y92]], [[3ub2]] – | + | **[[2y92]], [[3ub2]], [[4fz5]], [[4lqd]] – hTIRAP TIR domain 81-221 - human<br /> |
**[[5uzb]] – hMAL TIR domain - Cryo EM<br /> | **[[5uzb]] – hMAL TIR domain - Cryo EM<br /> | ||
**[[3ub3]], [[3ub4]] – hMAL TIR domain (mutant)<br /> | **[[3ub3]], [[3ub4]] – hMAL TIR domain (mutant)<br /> | ||
**[[2m1w]], [[2m1x]], [[2ndh]] – hMAL TIR domain (mutant) - NMR<br /> | **[[2m1w]], [[2m1x]], [[2ndh]] – hMAL TIR domain (mutant) - NMR<br /> | ||
**[[2m63]] – hMAL N-terminal domain - NMR<br /> | **[[2m63]] – hMAL N-terminal domain - NMR<br /> | ||
| + | **[[5t7q]] – hMAL residues 15-35 - NMR<br /> | ||
| - | *MyD88 | + | *MyD88 or myeloid differentiation primary response protein MyD88; Domains – death 12-163; TIR 157-296 |
| - | **[[ | + | **[[4dom]], [[4eo7]], [[7beq]], [[7ber]], [[7l6w]] – hMyD88 TIR domain 157-296<br /> |
**[[2z5v]] – hMyD88 TIR domain - NMR<br /> | **[[2z5v]] – hMyD88 TIR domain - NMR<br /> | ||
| + | **[[6i3n]] – hMyD88 death domain – Cryo EM<br /> | ||
| + | **[[3mop]] – hMyD88 death domain + IRAK-2 + IRAK-4<br /> | ||
*TRIF | *TRIF | ||
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**[[4c0m]] – hTRIF N-terminal domain <br /> | **[[4c0m]] – hTRIF N-terminal domain <br /> | ||
**[[4bsx]] – hTRIF N-terminal domain (mutant)<br /> | **[[4bsx]] – hTRIF N-terminal domain (mutant)<br /> | ||
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| + | *TcpB | ||
| + | |||
| + | **[[4lqc]], [[4c7m]] – TcpB TIR domain (mutant) – ''Brucella melitensis''<br /> | ||
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Current revision
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3D Structures of TIR domain-containing adapter protein
Updated on 25-April-2022
References
- ↑ O'Neill LA, Bowie AG. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol. 2007 May;7(5):353-64. PMID:17457343 doi:http://dx.doi.org/nri2079
