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6mib
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the ILK ATP-binding deficient mutant (L207W)/alpha-parvin core complex== | |
| + | <StructureSection load='6mib' size='340' side='right'caption='[[6mib]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6mib]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MIB FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mib OCA], [https://pdbe.org/6mib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mib RCSB], [https://www.ebi.ac.uk/pdbsum/6mib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mib ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. | ||
| - | + | ==See Also== | |
| - | + | *[[Parvin 3D structures|Parvin 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Fukuda | + | [[Category: Homo sapiens]] |
| - | [[Category: Qin | + | [[Category: Large Structures]] |
| + | [[Category: Fukuda K]] | ||
| + | [[Category: Qin J]] | ||
Current revision
Crystal structure of the ILK ATP-binding deficient mutant (L207W)/alpha-parvin core complex
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