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2qf4

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[[Image:2qf4.jpg|left|200px]]
 
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{{Structure
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==High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (orthorhombic form)==
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|PDB= 2qf4 |SIZE=350|CAPTION= <scene name='initialview01'>2qf4</scene>, resolution 1.200&Aring;
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<StructureSection load='2qf4' size='340' side='right'caption='[[2qf4]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[2qf4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QF4 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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|GENE= mreC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=171101 Streptococcus pneumoniae R6])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qf4 OCA], [https://pdbe.org/2qf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qf4 RCSB], [https://www.ebi.ac.uk/pdbsum/2qf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qf4 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2qf5|2QF5]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qf4 OCA], [http://www.ebi.ac.uk/pdbsum/2qf4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qf4 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/MREC_STRR6 MREC_STRR6] Involved in formation and maintenance of cell shape.[UniProtKB:Q01466]
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== Evolutionary Conservation ==
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'''High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (orthorhombic form)'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qf/2qf4_consurf.spt"</scriptWhenChecked>
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Bacterial cell shape is dictated by the cell wall, a plastic structure that must adapt to growth and division whilst retaining its function as a selectively permeable barrier. The modulation of cell wall structure is achieved by a variety of enzymatic functions, all of which must be spatially regulated in a precise manner. The membrane-spanning essential protein MreC has been identified as the central hub in this process, linking the bacterial cytoskeleton to a variety of cell wall-modifying enzymes. Additionally, MreC can form filaments, believed to run perpendicularly to the membrane. We present here the 1.2 A resolution crystal structure of the major periplasmic domain of Streptococcus pneumoniae MreC. The protein shows a novel arrangement of two barrel-shaped domains, one of which shows homology to a known protein oligomerization motif, with the other resembling a catalytic domain from a bacterial protease. We discuss the implications of these results for MreC function, and detail the structural features of the molecule that may be responsible for the binding of partner proteins.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2QF4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QF4 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qf4 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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High-resolution structure of the major periplasmic domain from the cell shape-determining filament MreC., Lovering AL, Strynadka NC, J Mol Biol. 2007 Sep 28;372(4):1034-44. Epub 2007 Jul 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17707860 17707860]
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Streptococcus pneumoniae r6]]
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[[Category: Streptococcus pneumoniae R6]]
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[[Category: Lovering, A L.]]
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[[Category: Lovering AL]]
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[[Category: Strynadka, N C.J.]]
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[[Category: Strynadka NCJ]]
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[[Category: filament a-lytic protease fold]]
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[[Category: structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:48:33 2008''
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Current revision

High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (orthorhombic form)

PDB ID 2qf4

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