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2qfc

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[[Image:2qfc.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of Bacillus thuringiensis PlcR complexed with PapR==
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|PDB= 2qfc |SIZE=350|CAPTION= <scene name='initialview01'>2qfc</scene>, resolution 2.600&Aring;
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<StructureSection load='2qfc' size='340' side='right'caption='[[2qfc]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>
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<table><tr><td colspan='2'>[[2qfc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis_serovar_israelensis_ATCC_35646 Bacillus thuringiensis serovar israelensis ATCC 35646]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QFC FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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|GENE= plcR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1428 Bacillus thuringiensis])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qfc OCA], [https://pdbe.org/2qfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qfc RCSB], [https://www.ebi.ac.uk/pdbsum/2qfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qfc ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qfc OCA], [http://www.ebi.ac.uk/pdbsum/2qfc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qfc RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/Q3EZ40_BACTI Q3EZ40_BACTI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qf/2qfc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qfc ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of Bacillus thuringiensis PlcR complexed with PapR'''
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==See Also==
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Gram-positive bacteria use a wealth of extracellular signaling peptides, so-called autoinducers, to regulate gene expression according to population densities. These "quorum sensing" systems control vital processes such as virulence, sporulation, and gene transfer. Using x-ray analysis, we determined the structure of PlcR, the major virulence regulator of the Bacillus cereus group, and obtained mechanistic insights into the effects of autoinducer binding. Our structural and phylogenetic analysis further suggests that all of those quorum sensors that bind directly to their autoinducer peptide derive from a common ancestor and form a single family (the RNPP family, for Rap/NprR/PlcR/PrgX) with conserved features. As a consequence, fundamentally different processes in different bacterial genera appear regulated by essentially the same autoinducer recognition mechanism. Our results shed light on virulence control by PlcR and elucidate origin and evolution of multicellular behavior in bacteria.
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[[Category: Bacillus thuringiensis serovar israelensis ATCC 35646]]
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[[Category: Large Structures]]
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==About this Structure==
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[[Category: Arold ST]]
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2QFC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QFC OCA].
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[[Category: Chaix D]]
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[[Category: Declerck N]]
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==Reference==
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[[Category: Hoh F]]
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Structure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria., Declerck N, Bouillaut L, Chaix D, Rugani N, Slamti L, Hoh F, Lereclus D, Arold ST, Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18490-5. Epub 2007 Nov 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17998541 17998541]
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[[Category: Rugani N]]
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[[Category: Bacillus thuringiensis]]
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[[Category: Protein complex]]
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[[Category: Arold, S T.]]
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[[Category: Chaix, D.]]
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[[Category: Declerck, N.]]
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[[Category: Hoh, F.]]
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[[Category: Rugani, N.]]
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[[Category: hth]]
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[[Category: tpr]]
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[[Category: transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:48:39 2008''
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Current revision

Crystal Structure of Bacillus thuringiensis PlcR complexed with PapR

PDB ID 2qfc

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