2wo6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (01:29, 21 November 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
==Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in complex with a consensus substrate peptide==
==Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in complex with a consensus substrate peptide==
-
<StructureSection load='2wo6' size='340' side='right' caption='[[2wo6]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+
<StructureSection load='2wo6' size='340' side='right'caption='[[2wo6]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2wo6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WO6 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2wo6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WO6 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D15:N-(5-{[(2S)-4-AMINO-2-(3-CHLOROPHENYL)BUTANOYL]AMINO}-1H-INDAZOL-3-YL)BENZAMIDE'>D15</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D15:N-(5-{[(2S)-4-AMINO-2-(3-CHLOROPHENYL)BUTANOYL]AMINO}-1H-INDAZOL-3-YL)BENZAMIDE'>D15</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vx3|2vx3]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wo6 OCA], [https://pdbe.org/2wo6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wo6 RCSB], [https://www.ebi.ac.uk/pdbsum/2wo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wo6 ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wo6 OCA], [http://pdbe.org/2wo6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wo6 RCSB], [http://www.ebi.ac.uk/pdbsum/2wo6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wo6 ProSAT]</span></td></tr>
+
</table>
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[https://omim.org/entry/614104 614104]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 15: Line 17:
<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2wo6_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2wo6_consurf.spt"</scriptWhenChecked>
-
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
Line 33: Line 35:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Dual-specificity kinase]]
+
[[Category: Homo sapiens]]
-
[[Category: Human]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H]]
+
[[Category: Synthetic construct]]
-
[[Category: Bountra, C]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Burgess-Brown, N]]
+
[[Category: Bountra C]]
-
[[Category: Delft, F von]]
+
[[Category: Burgess-Brown N]]
-
[[Category: Edwards, A]]
+
[[Category: Edwards A]]
-
[[Category: Elkins, J M]]
+
[[Category: Elkins JM]]
-
[[Category: Eswaran, J]]
+
[[Category: Eswaran J]]
-
[[Category: Fedorov, O]]
+
[[Category: Fedorov O]]
-
[[Category: Knapp, S]]
+
[[Category: Knapp S]]
-
[[Category: Muniz, J R.C]]
+
[[Category: Muniz JRC]]
-
[[Category: Phillips, C]]
+
[[Category: Phillips C]]
-
[[Category: Pike, A C.W]]
+
[[Category: Pike ACW]]
-
[[Category: Roos, A K]]
+
[[Category: Roos AK]]
-
[[Category: Soundararajan, M]]
+
[[Category: Soundararajan M]]
-
[[Category: Ugochukwu, E]]
+
[[Category: Ugochukwu E]]
-
[[Category: Wikstrom, M]]
+
[[Category: Wikstrom M]]
-
[[Category: Dyrk1]]
+
[[Category: Von Delft F]]
-
[[Category: Dyrk1a]]
+
-
[[Category: Kinase]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Serine/threonine-protein atp-binding]]
+
-
[[Category: Transferase]]
+
-
[[Category: Transferase peptide complex]]
+
-
[[Category: Transferase-peptide complex]]
+
-
[[Category: Tyrosine-protein kinase]]
+

Current revision

Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in complex with a consensus substrate peptide

PDB ID 2wo6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wo6"
Personal tools