2wjx
From Proteopedia
(Difference between revisions)
(One intermediate revision not shown.) | |||
Line 1: | Line 1: | ||
==Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 4.1 A resolution== | ==Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 4.1 A resolution== | ||
- | <StructureSection load='2wjx' size='340' side='right' caption='[[2wjx]], [[Resolution|resolution]] 4.10Å' scene=''> | + | <StructureSection load='2wjx' size='340' side='right'caption='[[2wjx]], [[Resolution|resolution]] 4.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[2wjx]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2wjx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WJX FirstGlance]. <br> |
- | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wjw|2wjw]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wjw|2wjw]]</div></td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjx OCA], [https://pdbe.org/2wjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wjx RCSB], [https://www.ebi.ac.uk/pdbsum/2wjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wjx ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/GRIA2_HUMAN GRIA2_HUMAN]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:20614889</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Line 30: | Line 30: | ||
==See Also== | ==See Also== | ||
- | *[[ | + | *[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
Line 36: | Line 36: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
+ | [[Category: Large Structures]] | ||
[[Category: Aricescu, A R]] | [[Category: Aricescu, A R]] | ||
[[Category: Clayton, A]] | [[Category: Clayton, A]] |
Current revision
Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 4.1 A resolution
|
Categories: Human | Large Structures | Aricescu, A R | Clayton, A | Gilbert, R J.C | Harlos, K | Jones, E Y | McIlhinney, R A.J | Siebold, C | Sutton, G C | Alternative splicing | Cell junction | Cell membrane | Glur2 | Glutamate receptor | Glycoprotein | Ion channel | Ion transport | Ionic channel | Lipoprotein | Membrane | Palmitate | Phosphoprotein | Polymorphism | Postsynaptic cell membrane | Receptor | Rna editing | Synapse | Synaptic plasticity | Transmembrane | Transport | Transport protein